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Effect of charge fluctuations on the permeation of ions through biological ion channels

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Published
Publication date1/12/2007
Host publicationNoise and Fluctuations - 19th International Conference on Noise and Fluctuations, ICNF 2007
PublisherAmerican Institute of Physics
Pages647-650
Number of pages4
ISBN (print)9780735404328
<mark>Original language</mark>English
Event19th International Conference on Noise and Fluctuations, ICNF2007 - Tokyo, Japan
Duration: 9/09/200714/09/2007

Conference

Conference19th International Conference on Noise and Fluctuations, ICNF2007
Country/TerritoryJapan
CityTokyo
Period9/09/0714/09/07

Publication series

NameAIP Conference Proceedings
Volume922
ISSN (Print)0094-243X
ISSN (electronic)1551-7616

Conference

Conference19th International Conference on Noise and Fluctuations, ICNF2007
Country/TerritoryJapan
CityTokyo
Period9/09/0714/09/07

Abstract

The effect of charge fluctuations at the mouth of an open ion channel on its conduction mechanism is analyzed within the framework of self-consistent Brownian dynamics simulations. It is shown that volume charge fluctuations at the channel mouth can be modelled as a generalized shot noise and result in strong modulation of the potential barrier for an ion at the selectivity site, on a sub-nanosecond time scale.