Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide

Biomedical and Life Sciences

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Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide. / Taylor, Mark; Moore, Susan; Mourtas, Spyridon et al.
In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 7, No. 5, 10.2011, p. 541-550.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Taylor, M, Moore, S, Mourtas, S, Niarakis, A, Re, F, Zona, C, La Ferla, B, Nicotra, F, Masserini, M, Antimisiaris, SG, Gregori, M & Allsop, D 2011, 'Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 7, no. 5, pp. 541-550. https://doi.org/10.1016/j.nano.2011.06.015

APA

Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., La Ferla, B., Nicotra, F., Masserini, M., Antimisiaris, S. G., Gregori, M., & Allsop, D. (2011). Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide. Nanomedicine: Nanotechnology, Biology, and Medicine, 7(5), 541-550. https://doi.org/10.1016/j.nano.2011.06.015

Vancouver

Taylor M, Moore S, Mourtas S, Niarakis A, Re F, Zona C et al. Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide. Nanomedicine: Nanotechnology, Biology, and Medicine. 2011 Oct;7(5):541-550. doi: 10.1016/j.nano.2011.06.015

Author

Taylor, Mark ; Moore, Susan ; Mourtas, Spyridon et al. / Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2011 ; Vol. 7, No. 5. pp. 541-550.

Bibtex

@article{c6cfcb77a4c84f1da10f1872bb44d384,

title = "Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide",

abstract = "The effect of various types of nanoliposomes (associated with curcumin, phosphatidic acid, cardiolipin, or GM1 ganglioside) on the aggregation of the amyloid-β(1-42) (Aβ(1-42)) peptide was investigated. Nanoliposomes incorporating curcumin (curcumin-liposomes) were prepared by adding curcumin in the lipid phase during liposome preparation, whereas curcumin surface-decorated liposomes were prepared by using a curcumin-lipid conjugate (lipid-S-curcumin liposomes) or by attaching a curcumin derivative on preformed liposomes by click chemistry (click-curcumin liposomes). The lipid ligands (phosphatidic acid, cardiolipin, or GM1) were also incorporated into nanoliposomes during their formation. All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Aβ in vitro. Of the three forms of curcumin liposomes tested, the click-curcumin type was by far the most effective. Liposomes with lipid ligands only inhibited Aβ fibril and oligomer formation at a very high ratio of liposome to peptide. Curcumin-based liposomes could be further developed as a novel treatment for Alzheimer's disease.",

keywords = "Liposomes, Curcumin , Amyloid-β , Oligomer, Fibril",

author = "Mark Taylor and Susan Moore and Spyridon Mourtas and Anna Niarakis and Francesca Re and Cristiano Zona and {La Ferla}, Barbara and Francesco Nicotra and Massimo Masserini and Antimisiaris, {Sophia G} and Maria Gregori and David Allsop",

year = "2011",

month = oct,

doi = "10.1016/j.nano.2011.06.015",

language = "English",

volume = "7",

pages = "541--550",

journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",

publisher = "Elsevier Inc.",

number = "5",

}

RIS

TY - JOUR

T1 - Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide

AU - Taylor, Mark

AU - Moore, Susan

AU - Mourtas, Spyridon

AU - Niarakis, Anna

AU - Re, Francesca

AU - Zona, Cristiano

AU - La Ferla, Barbara

AU - Nicotra, Francesco

AU - Masserini, Massimo

AU - Antimisiaris, Sophia G

AU - Gregori, Maria

AU - Allsop, David

PY - 2011/10

Y1 - 2011/10

N2 - The effect of various types of nanoliposomes (associated with curcumin, phosphatidic acid, cardiolipin, or GM1 ganglioside) on the aggregation of the amyloid-β(1-42) (Aβ(1-42)) peptide was investigated. Nanoliposomes incorporating curcumin (curcumin-liposomes) were prepared by adding curcumin in the lipid phase during liposome preparation, whereas curcumin surface-decorated liposomes were prepared by using a curcumin-lipid conjugate (lipid-S-curcumin liposomes) or by attaching a curcumin derivative on preformed liposomes by click chemistry (click-curcumin liposomes). The lipid ligands (phosphatidic acid, cardiolipin, or GM1) were also incorporated into nanoliposomes during their formation. All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Aβ in vitro. Of the three forms of curcumin liposomes tested, the click-curcumin type was by far the most effective. Liposomes with lipid ligands only inhibited Aβ fibril and oligomer formation at a very high ratio of liposome to peptide. Curcumin-based liposomes could be further developed as a novel treatment for Alzheimer's disease.

AB - The effect of various types of nanoliposomes (associated with curcumin, phosphatidic acid, cardiolipin, or GM1 ganglioside) on the aggregation of the amyloid-β(1-42) (Aβ(1-42)) peptide was investigated. Nanoliposomes incorporating curcumin (curcumin-liposomes) were prepared by adding curcumin in the lipid phase during liposome preparation, whereas curcumin surface-decorated liposomes were prepared by using a curcumin-lipid conjugate (lipid-S-curcumin liposomes) or by attaching a curcumin derivative on preformed liposomes by click chemistry (click-curcumin liposomes). The lipid ligands (phosphatidic acid, cardiolipin, or GM1) were also incorporated into nanoliposomes during their formation. All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Aβ in vitro. Of the three forms of curcumin liposomes tested, the click-curcumin type was by far the most effective. Liposomes with lipid ligands only inhibited Aβ fibril and oligomer formation at a very high ratio of liposome to peptide. Curcumin-based liposomes could be further developed as a novel treatment for Alzheimer's disease.

KW - Liposomes

KW - Curcumin

KW - Amyloid-β

KW - Oligomer

KW - Fibril

UR - http://www.scopus.com/inward/record.url?scp=80053216654&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2011.06.015

DO - 10.1016/j.nano.2011.06.015

M3 - Journal article

C2 - 21722618

VL - 7

SP - 541

EP - 550

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

IS - 5

ER -

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