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Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

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Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation. / Ivanova, Anna; Syromotina, Dina; Shkarina, Svetlana; Shkarin, Roman; Cecilia, Angelica; Weinhardt, Venera; Baumbach, Tilo; Saveleva, Mariia; Gorin, Dmitry; Douglas, Timothy Edward Lim; Parakhonskiy, Bogdan; Skirtach, Andre G.; Cools, Pieter; De Geyter, Nathalie; Morent, Rino; Oehr, Christian; Surmeneva, Maria; Surmenev, Roman.

In: RSC Advances, Vol. 8, No. 68, 22.11.2018, p. 39106-39114.

Research output: Contribution to journalJournal article

Harvard

Ivanova, A, Syromotina, D, Shkarina, S, Shkarin, R, Cecilia, A, Weinhardt, V, Baumbach, T, Saveleva, M, Gorin, D, Douglas, TEL, Parakhonskiy, B, Skirtach, AG, Cools, P, De Geyter, N, Morent, R, Oehr, C, Surmeneva, M & Surmenev, R 2018, 'Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation', RSC Advances, vol. 8, no. 68, pp. 39106-39114. https://doi.org/10.1039/c8ra07386d

APA

Ivanova, A., Syromotina, D., Shkarina, S., Shkarin, R., Cecilia, A., Weinhardt, V., Baumbach, T., Saveleva, M., Gorin, D., Douglas, T. E. L., Parakhonskiy, B., Skirtach, A. G., Cools, P., De Geyter, N., Morent, R., Oehr, C., Surmeneva, M., & Surmenev, R. (2018). Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation. RSC Advances, 8(68), 39106-39114. https://doi.org/10.1039/c8ra07386d

Vancouver

Ivanova A, Syromotina D, Shkarina S, Shkarin R, Cecilia A, Weinhardt V et al. Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation. RSC Advances. 2018 Nov 22;8(68):39106-39114. https://doi.org/10.1039/c8ra07386d

Author

Ivanova, Anna ; Syromotina, Dina ; Shkarina, Svetlana ; Shkarin, Roman ; Cecilia, Angelica ; Weinhardt, Venera ; Baumbach, Tilo ; Saveleva, Mariia ; Gorin, Dmitry ; Douglas, Timothy Edward Lim ; Parakhonskiy, Bogdan ; Skirtach, Andre G. ; Cools, Pieter ; De Geyter, Nathalie ; Morent, Rino ; Oehr, Christian ; Surmeneva, Maria ; Surmenev, Roman. / Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation. In: RSC Advances. 2018 ; Vol. 8, No. 68. pp. 39106-39114.

Bibtex

@article{7a4c8977df004c76bd7be2a67ad46c2b,
title = "Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation",
abstract = "This article reports on a study of the mineralisation behaviour of CaCO3 deposited on electrospun poly(ϵ-caprolactone) (PCL) scaffolds preliminarily treated with low-temperature plasma. This work was aimed at developing an approach that improves the wettability and permeability of PCL scaffolds in order to obtain a superior composite coated with highly porous CaCO3, which is a prerequisite for biomedical scaffolds used for drug delivery. Since PCL is a synthetic polymer that lacks functional groups, plasma processing of PCL scaffolds in O2, NH3, and Ar atmospheres enables introduction of highly reactive chemical groups, which influence the interaction between organic and inorganic phases and govern the nucleation, crystal growth, particle morphology, and phase composition of the CaCO3 coating. Our studies showed that the plasma treatment induced the formation of O- and N-containing polar functional groups on the scaffold surface, which caused an increase in the PCL surface hydrophilicity. Mineralisation of the PCL scaffolds was performed by inducing precipitation of CaCO3 particles on the surface of polymer fibres from a mixture of CaCl2- and Na2CO3-saturated solutions. The presence of highly porous vaterite and nonporous calcite crystal phases in the obtained coating was established. Our findings confirmed that preferential growth of the vaterite phase occurred in the O2-plasma-treated PCL scaffold and that the coating formed on this scaffold was smoother and more homogenous than those formed on the untreated PCL scaffold and the Ar- and NH3-plasma-treated PCL scaffolds. A more detailed three-dimensional assessment of the penetration depth of CaCO3 into the PCL scaffold was performed by high-resolution micro-computed tomography. The assessment revealed that O2-plasma treatment of the PCL scaffold caused CaCO3 to nucleate and precipitate much deeper inside the porous structure. From our findings, we conclude that O2-plasma treatment is preferable for PCL scaffold surface modification from the viewpoint of use of the PCL/CaCO3 composite as a drug delivery platform for tissue engineering. {\textcopyright} 2018 The Royal Society of Chemistry.",
keywords = "Ammonia, Calcite, Calcium carbonate, Computerized tomography, Controlled drug delivery, Hydrophilicity, Mineralogy, Phase composition, Plasma applications, Plastic coatings, Sodium Carbonate, Sodium compounds, Surface treatment, Targeted drug delivery, Temperature, Low temperature plasmas, Low-Temperature Plasma Treatment, Microcomputed tomography, Particle morphologies, Polar functional groups, Preferential growth, Saturated solutions, Surface hydrophilicity, Scaffolds (biology)",
author = "Anna Ivanova and Dina Syromotina and Svetlana Shkarina and Roman Shkarin and Angelica Cecilia and Venera Weinhardt and Tilo Baumbach and Mariia Saveleva and Dmitry Gorin and Douglas, {Timothy Edward Lim} and Bogdan Parakhonskiy and Skirtach, {Andre G.} and Pieter Cools and {De Geyter}, Nathalie and Rino Morent and Christian Oehr and Maria Surmeneva and Roman Surmenev",
year = "2018",
month = nov,
day = "22",
doi = "10.1039/c8ra07386d",
language = "English",
volume = "8",
pages = "39106--39114",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "68",

}

RIS

TY - JOUR

T1 - Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

AU - Ivanova, Anna

AU - Syromotina, Dina

AU - Shkarina, Svetlana

AU - Shkarin, Roman

AU - Cecilia, Angelica

AU - Weinhardt, Venera

AU - Baumbach, Tilo

AU - Saveleva, Mariia

AU - Gorin, Dmitry

AU - Douglas, Timothy Edward Lim

AU - Parakhonskiy, Bogdan

AU - Skirtach, Andre G.

AU - Cools, Pieter

AU - De Geyter, Nathalie

AU - Morent, Rino

AU - Oehr, Christian

AU - Surmeneva, Maria

AU - Surmenev, Roman

PY - 2018/11/22

Y1 - 2018/11/22

N2 - This article reports on a study of the mineralisation behaviour of CaCO3 deposited on electrospun poly(ϵ-caprolactone) (PCL) scaffolds preliminarily treated with low-temperature plasma. This work was aimed at developing an approach that improves the wettability and permeability of PCL scaffolds in order to obtain a superior composite coated with highly porous CaCO3, which is a prerequisite for biomedical scaffolds used for drug delivery. Since PCL is a synthetic polymer that lacks functional groups, plasma processing of PCL scaffolds in O2, NH3, and Ar atmospheres enables introduction of highly reactive chemical groups, which influence the interaction between organic and inorganic phases and govern the nucleation, crystal growth, particle morphology, and phase composition of the CaCO3 coating. Our studies showed that the plasma treatment induced the formation of O- and N-containing polar functional groups on the scaffold surface, which caused an increase in the PCL surface hydrophilicity. Mineralisation of the PCL scaffolds was performed by inducing precipitation of CaCO3 particles on the surface of polymer fibres from a mixture of CaCl2- and Na2CO3-saturated solutions. The presence of highly porous vaterite and nonporous calcite crystal phases in the obtained coating was established. Our findings confirmed that preferential growth of the vaterite phase occurred in the O2-plasma-treated PCL scaffold and that the coating formed on this scaffold was smoother and more homogenous than those formed on the untreated PCL scaffold and the Ar- and NH3-plasma-treated PCL scaffolds. A more detailed three-dimensional assessment of the penetration depth of CaCO3 into the PCL scaffold was performed by high-resolution micro-computed tomography. The assessment revealed that O2-plasma treatment of the PCL scaffold caused CaCO3 to nucleate and precipitate much deeper inside the porous structure. From our findings, we conclude that O2-plasma treatment is preferable for PCL scaffold surface modification from the viewpoint of use of the PCL/CaCO3 composite as a drug delivery platform for tissue engineering. © 2018 The Royal Society of Chemistry.

AB - This article reports on a study of the mineralisation behaviour of CaCO3 deposited on electrospun poly(ϵ-caprolactone) (PCL) scaffolds preliminarily treated with low-temperature plasma. This work was aimed at developing an approach that improves the wettability and permeability of PCL scaffolds in order to obtain a superior composite coated with highly porous CaCO3, which is a prerequisite for biomedical scaffolds used for drug delivery. Since PCL is a synthetic polymer that lacks functional groups, plasma processing of PCL scaffolds in O2, NH3, and Ar atmospheres enables introduction of highly reactive chemical groups, which influence the interaction between organic and inorganic phases and govern the nucleation, crystal growth, particle morphology, and phase composition of the CaCO3 coating. Our studies showed that the plasma treatment induced the formation of O- and N-containing polar functional groups on the scaffold surface, which caused an increase in the PCL surface hydrophilicity. Mineralisation of the PCL scaffolds was performed by inducing precipitation of CaCO3 particles on the surface of polymer fibres from a mixture of CaCl2- and Na2CO3-saturated solutions. The presence of highly porous vaterite and nonporous calcite crystal phases in the obtained coating was established. Our findings confirmed that preferential growth of the vaterite phase occurred in the O2-plasma-treated PCL scaffold and that the coating formed on this scaffold was smoother and more homogenous than those formed on the untreated PCL scaffold and the Ar- and NH3-plasma-treated PCL scaffolds. A more detailed three-dimensional assessment of the penetration depth of CaCO3 into the PCL scaffold was performed by high-resolution micro-computed tomography. The assessment revealed that O2-plasma treatment of the PCL scaffold caused CaCO3 to nucleate and precipitate much deeper inside the porous structure. From our findings, we conclude that O2-plasma treatment is preferable for PCL scaffold surface modification from the viewpoint of use of the PCL/CaCO3 composite as a drug delivery platform for tissue engineering. © 2018 The Royal Society of Chemistry.

KW - Ammonia

KW - Calcite

KW - Calcium carbonate

KW - Computerized tomography

KW - Controlled drug delivery

KW - Hydrophilicity

KW - Mineralogy

KW - Phase composition

KW - Plasma applications

KW - Plastic coatings

KW - Sodium Carbonate

KW - Sodium compounds

KW - Surface treatment

KW - Targeted drug delivery

KW - Temperature

KW - Low temperature plasmas

KW - Low-Temperature Plasma Treatment

KW - Microcomputed tomography

KW - Particle morphologies

KW - Polar functional groups

KW - Preferential growth

KW - Saturated solutions

KW - Surface hydrophilicity

KW - Scaffolds (biology)

U2 - 10.1039/c8ra07386d

DO - 10.1039/c8ra07386d

M3 - Journal article

VL - 8

SP - 39106

EP - 39114

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 68

ER -