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Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model

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Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model. / Duan, Luchun; Palanisami, Thavamani; Liu, Yanju et al.
In: Environment International, Vol. 70, 09.2014, p. 192-202.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Duan, L, Palanisami, T, Liu, Y, Dong, Z, Mallavarapu, M, Kuchel, T, Semple, KT & Naidu, R 2014, 'Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model', Environment International, vol. 70, pp. 192-202. https://doi.org/10.1016/j.envint.2014.05.017

APA

Duan, L., Palanisami, T., Liu, Y., Dong, Z., Mallavarapu, M., Kuchel, T., Semple, K. T., & Naidu, R. (2014). Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model. Environment International, 70, 192-202. https://doi.org/10.1016/j.envint.2014.05.017

Vancouver

Duan L, Palanisami T, Liu Y, Dong Z, Mallavarapu M, Kuchel T et al. Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model. Environment International. 2014 Sept;70:192-202. doi: 10.1016/j.envint.2014.05.017

Author

Duan, Luchun ; Palanisami, Thavamani ; Liu, Yanju et al. / Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model. In: Environment International. 2014 ; Vol. 70. pp. 192-202.

Bibtex

@article{8380b36203c64a3baa92190f92645b7c,
title = "Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model",
abstract = "Oral bioavailability of benzo[a]pyrene (B[a]P) was studied in a swine model using eight spiked soil samples after incubation for 50 and/or 90days. Silica sand was used as a reference material and the relative bioavailability (RB) of B[a]P in soils was calculated as the quotient of the area under the plasma B[a]P curve (AUC) for soil and AUC for the silica sand. Significantly reduced RB was observed in all study soils after 90days ageing, ranging from 22.1±0.4% to 62.7±10.1%, except for one very sandy soil (sand content 87.6%) where RB was unchanged (108.1±8.0%). Apart from this, bioavailability decreased during ageing with the decrease (from day 50 to day 90) being only significant for a clayey soil containing expandable clay minerals. Statistical analyses of B[a]P RB at day 90 (eight soils) and soil properties showed no direct correlation between RB and specific soil properties such as total organic carbon (TOC) and clay content which were commonly linked to organic contaminant sequestration. However, strongly significant relationships (p<0.001) were found between RB and the fine particle associated carbon (FPAC) defined as (Silt+Clay)/TOC, and between RB and the soil mesopore (<6nm; p<0.001) fraction, after two samples with high pH and high EC being excluded from the analyses. The bioaccessibility estimated by four in vitro extraction methods: dichloromethane/acetone sonication (DCM/Ace), butanol vortex (BuOH), hydroxypropyl-β-cyclodextrin extraction (HPCD) and Milli Q water leaching methods at different sampling time (1day, 50days and 90days after spiking) also showed a decreasing trend. Significant correlations were found between B[a]P RB and DCM/Ace (R(2)=0.67, p<0.05) extractable fraction and BuOH (R(2)=0.75, p<0.01) extractable fraction.",
keywords = "Oral bioavailability, Benzo[a]pyrene, Swine model , Soil properties , Extractability , Ageing effect",
author = "Luchun Duan and Thavamani Palanisami and Yanju Liu and Zhaomin Dong and Megharaj Mallavarapu and Tim Kuchel and Semple, {Kirk T.} and Ravi Naidu",
year = "2014",
month = sep,
doi = "10.1016/j.envint.2014.05.017",
language = "English",
volume = "70",
pages = "192--202",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model

AU - Duan, Luchun

AU - Palanisami, Thavamani

AU - Liu, Yanju

AU - Dong, Zhaomin

AU - Mallavarapu, Megharaj

AU - Kuchel, Tim

AU - Semple, Kirk T.

AU - Naidu, Ravi

PY - 2014/9

Y1 - 2014/9

N2 - Oral bioavailability of benzo[a]pyrene (B[a]P) was studied in a swine model using eight spiked soil samples after incubation for 50 and/or 90days. Silica sand was used as a reference material and the relative bioavailability (RB) of B[a]P in soils was calculated as the quotient of the area under the plasma B[a]P curve (AUC) for soil and AUC for the silica sand. Significantly reduced RB was observed in all study soils after 90days ageing, ranging from 22.1±0.4% to 62.7±10.1%, except for one very sandy soil (sand content 87.6%) where RB was unchanged (108.1±8.0%). Apart from this, bioavailability decreased during ageing with the decrease (from day 50 to day 90) being only significant for a clayey soil containing expandable clay minerals. Statistical analyses of B[a]P RB at day 90 (eight soils) and soil properties showed no direct correlation between RB and specific soil properties such as total organic carbon (TOC) and clay content which were commonly linked to organic contaminant sequestration. However, strongly significant relationships (p<0.001) were found between RB and the fine particle associated carbon (FPAC) defined as (Silt+Clay)/TOC, and between RB and the soil mesopore (<6nm; p<0.001) fraction, after two samples with high pH and high EC being excluded from the analyses. The bioaccessibility estimated by four in vitro extraction methods: dichloromethane/acetone sonication (DCM/Ace), butanol vortex (BuOH), hydroxypropyl-β-cyclodextrin extraction (HPCD) and Milli Q water leaching methods at different sampling time (1day, 50days and 90days after spiking) also showed a decreasing trend. Significant correlations were found between B[a]P RB and DCM/Ace (R(2)=0.67, p<0.05) extractable fraction and BuOH (R(2)=0.75, p<0.01) extractable fraction.

AB - Oral bioavailability of benzo[a]pyrene (B[a]P) was studied in a swine model using eight spiked soil samples after incubation for 50 and/or 90days. Silica sand was used as a reference material and the relative bioavailability (RB) of B[a]P in soils was calculated as the quotient of the area under the plasma B[a]P curve (AUC) for soil and AUC for the silica sand. Significantly reduced RB was observed in all study soils after 90days ageing, ranging from 22.1±0.4% to 62.7±10.1%, except for one very sandy soil (sand content 87.6%) where RB was unchanged (108.1±8.0%). Apart from this, bioavailability decreased during ageing with the decrease (from day 50 to day 90) being only significant for a clayey soil containing expandable clay minerals. Statistical analyses of B[a]P RB at day 90 (eight soils) and soil properties showed no direct correlation between RB and specific soil properties such as total organic carbon (TOC) and clay content which were commonly linked to organic contaminant sequestration. However, strongly significant relationships (p<0.001) were found between RB and the fine particle associated carbon (FPAC) defined as (Silt+Clay)/TOC, and between RB and the soil mesopore (<6nm; p<0.001) fraction, after two samples with high pH and high EC being excluded from the analyses. The bioaccessibility estimated by four in vitro extraction methods: dichloromethane/acetone sonication (DCM/Ace), butanol vortex (BuOH), hydroxypropyl-β-cyclodextrin extraction (HPCD) and Milli Q water leaching methods at different sampling time (1day, 50days and 90days after spiking) also showed a decreasing trend. Significant correlations were found between B[a]P RB and DCM/Ace (R(2)=0.67, p<0.05) extractable fraction and BuOH (R(2)=0.75, p<0.01) extractable fraction.

KW - Oral bioavailability

KW - Benzo[a]pyrene

KW - Swine model

KW - Soil properties

KW - Extractability

KW - Ageing effect

U2 - 10.1016/j.envint.2014.05.017

DO - 10.1016/j.envint.2014.05.017

M3 - Journal article

C2 - 24937044

VL - 70

SP - 192

EP - 202

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -