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Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

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<mark>Journal publication date</mark>1/02/2015
<mark>Journal</mark>Catalysis Science and Technology
Issue number2
Volume5
Number of pages7
Pages (from-to)690-696
Publication statusPublished
Early online date11/09/14
Original languageEnglish

Abstract

Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.