TY - JOUR

T1 - Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

AU - Elmekawy, A. A.

AU - Sweeney, J. B.

AU - Brown, D. R.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.

AB - Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.

U2 - 10.1039/c4cy00970c

DO - 10.1039/c4cy00970c

M3 - Journal article

AN - SCOPUS:84927802639

VL - 5

SP - 690

EP - 696

JO - Catalysis Science and Technology

JF - Catalysis Science and Technology

SN - 2044-4753

IS - 2

ER -