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Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine

Research output: Contribution to journalReview article

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  • Saad B. Qasim
  • Muhammad S. Zafar
  • Shariq Najeeb
  • Zohaib Khurshid
  • Altaf H. Shah
  • Shehriar Husain
  • Ihtesham Ur Rehman
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Article number407
<mark>Journal publication date</mark>02/2018
<mark>Journal</mark>International Journal of Molecular Sciences
Issue number2
Volume19
Number of pages26
Publication statusPublished
Early online date30/01/18
Original languageEnglish

Abstract

Electrospinning has been used for decades to generate nano-fibres via an electrically charged jet of polymer solution. This process is established on a spinning technique, using electrostatic forces to produce fine fibres from polymer solutions. Amongst, the electrospinning of available biopolymers (silk, cellulose, collagen, gelatine and hyaluronic acid), chitosan (CH) has shown a favourable outcome for tissue regeneration applications. The aim of the current review is to assess the current literature about electrospinning chitosan and its composite formulations for creating fibres in combination with other natural polymers to be employed in tissue engineering. In addition, various polymers blended with chitosan for electrospinning have been discussed in terms of their potential biomedical applications. The review shows that evidence exists in support of the favourable properties and biocompatibility of chitosan electrospun composite biomaterials for a range of applications. However, further research and in vivo studies are required to translate these materials from the laboratory to clinical applications.