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Elimination kinetic model for organic chemicals in earthworms.

Research output: Contribution to journalJournal article

Published

  • N. Dimitrova
  • S. Dimitrov
  • Denitsa Georgieva
  • C. A. M. Van Gestel
  • P. Hankard
  • D. Spurgeon
  • Hong Li
  • O. Mekenyan
Journal publication date15/08/2010
JournalScience of the Total Environment
Journal number18
Volume408
Number of pages7
Pages3787-3793
Original languageEnglish

Abstract

Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms.