Home > Research > Publications & Outputs > Elimination kinetic model for organic chemicals...

Research

Links

Text available via DOI:

Keywords

View graph of relations

Elimination kinetic model for organic chemicals in earthworms.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Elimination kinetic model for organic chemicals in earthworms. / Dimitrova, N.; Dimitrov, S.; Georgieva, Denitsa et al.
In: Science of the Total Environment, Vol. 408, No. 18, 15.08.2010, p. 3787-3793.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Dimitrova, N, Dimitrov, S, Georgieva, D, Van Gestel, CAM, Hankard, P, Spurgeon, D, Li, H & Mekenyan, O 2010, 'Elimination kinetic model for organic chemicals in earthworms.', Science of the Total Environment, vol. 408, no. 18, pp. 3787-3793. https://doi.org/10.1016/j.scitotenv.2010.01.064

APA

Dimitrova, N., Dimitrov, S., Georgieva, D., Van Gestel, C. A. M., Hankard, P., Spurgeon, D., Li, H., & Mekenyan, O. (2010). Elimination kinetic model for organic chemicals in earthworms. Science of the Total Environment, 408(18), 3787-3793. https://doi.org/10.1016/j.scitotenv.2010.01.064

Vancouver

Dimitrova N, Dimitrov S, Georgieva D, Van Gestel CAM, Hankard P, Spurgeon D et al. Elimination kinetic model for organic chemicals in earthworms. Science of the Total Environment. 2010 Aug 15;408(18):3787-3793. doi: 10.1016/j.scitotenv.2010.01.064

Author

Dimitrova, N. ; Dimitrov, S. ; Georgieva, Denitsa et al. / Elimination kinetic model for organic chemicals in earthworms. In: Science of the Total Environment. 2010 ; Vol. 408, No. 18. pp. 3787-3793.

Bibtex

@article{890a991ac1e34c74b4e0da7ea6be032d,
title = "Elimination kinetic model for organic chemicals in earthworms.",
abstract = "Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms.",
keywords = "QSAR, Elimination, PAHs, Earthworms",
author = "N. Dimitrova and S. Dimitrov and Denitsa Georgieva and {Van Gestel}, {C. A. M.} and P. Hankard and D. Spurgeon and Hong Li and O. Mekenyan",
year = "2010",
month = aug,
day = "15",
doi = "10.1016/j.scitotenv.2010.01.064",
language = "English",
volume = "408",
pages = "3787--3793",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier Science B.V.",
number = "18",

}

RIS

TY - JOUR

T1 - Elimination kinetic model for organic chemicals in earthworms.

AU - Dimitrova, N.

AU - Dimitrov, S.

AU - Georgieva, Denitsa

AU - Van Gestel, C. A. M.

AU - Hankard, P.

AU - Spurgeon, D.

AU - Li, Hong

AU - Mekenyan, O.

PY - 2010/8/15

Y1 - 2010/8/15

N2 - Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms.

AB - Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms.

KW - QSAR

KW - Elimination

KW - PAHs

KW - Earthworms

U2 - 10.1016/j.scitotenv.2010.01.064

DO - 10.1016/j.scitotenv.2010.01.064

M3 - Journal article

VL - 408

SP - 3787

EP - 3793

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

IS - 18

ER -