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Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate.

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Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate. / Camporesi, Silvia; Cavaliere, Giulia.
In: Personalized Medicine, Vol. 13, No. 6, 01.11.2016, p. 575-586.

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Camporesi S, Cavaliere G. Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate. Personalized Medicine. 2016 Nov 1;13(6):575-586. Epub 2016 Oct 28. doi: 10.2217/pme-2016-0047

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@article{720b376dca3d4b50affa958ec5dade7a,
title = "Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate.",
abstract = "This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days.",
keywords = "bioethics, CRISPR, embryo research, gene editing, germline, stem cells",
author = "Silvia Camporesi and Giulia Cavaliere",
year = "2016",
month = nov,
day = "1",
doi = "10.2217/pme-2016-0047",
language = "English",
volume = "13",
pages = "575--586",
journal = "Personalized Medicine",
issn = "1741-0541",
publisher = "Future Medicine Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate.

AU - Camporesi, Silvia

AU - Cavaliere, Giulia

PY - 2016/11/1

Y1 - 2016/11/1

N2 - This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days.

AB - This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days.

KW - bioethics

KW - CRISPR

KW - embryo research

KW - gene editing

KW - germline

KW - stem cells

UR - http://europepmc.org/abstract/med/28757883

U2 - 10.2217/pme-2016-0047

DO - 10.2217/pme-2016-0047

M3 - Journal article

C2 - 28757883

VL - 13

SP - 575

EP - 586

JO - Personalized Medicine

JF - Personalized Medicine

SN - 1741-0541

IS - 6

ER -