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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate.
AU - Camporesi, Silvia
AU - Cavaliere, Giulia
PY - 2016/11/1
Y1 - 2016/11/1
N2 - This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days.
AB - This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days.
KW - bioethics
KW - CRISPR
KW - embryo research
KW - gene editing
KW - germline
KW - stem cells
UR - http://europepmc.org/abstract/med/28757883
U2 - 10.2217/pme-2016-0047
DO - 10.2217/pme-2016-0047
M3 - Journal article
C2 - 28757883
VL - 13
SP - 575
EP - 586
JO - Personalized Medicine
JF - Personalized Medicine
SN - 1741-0541
IS - 6
ER -