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Engaging with Raman spectroscopy to investigate antibody aggregation

Research output: Contribution to journalLiterature review

Published
<mark>Journal publication date</mark>7/07/2018
<mark>Journal</mark>Antibodies
Number of pages12
StatePublished
Original languageEnglish

Abstract

In the last decade, a number of studies have successfully demonstrated Raman spectroscopy as an emerging analytical technique for monitoring antibody aggregation, especially in the context of drug development and formulation. Raman spectroscopy is a robust method for investigating protein conformational changes, even in highly concentrated antibody solutions. It is non-destructive, reproducible and can probe samples in an aqueous environment. In this review, we focus on the application and challenges associated with using Raman spectroscopy as a tool to study antibody aggregates.