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Enteroendocrine cells: neglected players in gastrointestinal disorders?

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Enteroendocrine cells : neglected players in gastrointestinal disorders? / Moran, Gordon W.; Leslie, Fiona C.; Levison, Scott E.; Worthington, J; McLaughlin, John T.

In: Therapeutic Advances in Gastroenterology, Vol. 1, No. 1, 07.2008, p. 51-60.

Research output: Contribution to journalJournal article

Harvard

Moran, GW, Leslie, FC, Levison, SE, Worthington, J & McLaughlin, JT 2008, 'Enteroendocrine cells: neglected players in gastrointestinal disorders?', Therapeutic Advances in Gastroenterology, vol. 1, no. 1, pp. 51-60. https://doi.org/10.1177/1756283X08093943

APA

Moran, G. W., Leslie, F. C., Levison, S. E., Worthington, J., & McLaughlin, J. T. (2008). Enteroendocrine cells: neglected players in gastrointestinal disorders? Therapeutic Advances in Gastroenterology, 1(1), 51-60. https://doi.org/10.1177/1756283X08093943

Vancouver

Moran GW, Leslie FC, Levison SE, Worthington J, McLaughlin JT. Enteroendocrine cells: neglected players in gastrointestinal disorders? Therapeutic Advances in Gastroenterology. 2008 Jul;1(1):51-60. https://doi.org/10.1177/1756283X08093943

Author

Moran, Gordon W. ; Leslie, Fiona C. ; Levison, Scott E. ; Worthington, J ; McLaughlin, John T. / Enteroendocrine cells : neglected players in gastrointestinal disorders?. In: Therapeutic Advances in Gastroenterology. 2008 ; Vol. 1, No. 1. pp. 51-60.

Bibtex

@article{75f5d29d715642879c446b3013fbb4f8,
title = "Enteroendocrine cells: neglected players in gastrointestinal disorders?",
abstract = "Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body. They secrete multiple regulatory molecules which control physiological and homeostatic functions, particularly postprandial secretion and motility. Their key purpose is to act as sensors of luminal contents, either in a classical endocrine fashion, or by a paracrine effect on proximate cells, notably vagal afferent fibres. They also play a pivotal role in the control of food intake, and emerging data add roles in mucosal immunity and repair. We propose that EEC are fundamental in several gastrointestinal pathologies, notably Post-infectious Irritable Bowel Syndrome, infectious enteritis, and possibly inflammatory bowel disease. Further work is needed to fully illustrate the importance, detailed biology and therapeutic potential of these frequently overlooked cells.",
keywords = "Enteroendocrine cells, innate immunity, inflammation , inflammatory bowel disease, irritable bowel syndrome, anendocrinosis",
author = "Moran, {Gordon W.} and Leslie, {Fiona C.} and Levison, {Scott E.} and J Worthington and McLaughlin, {John T.}",
year = "2008",
month = jul,
doi = "10.1177/1756283X08093943",
language = "English",
volume = "1",
pages = "51--60",
journal = "Therapeutic Advances in Gastroenterology",
issn = "1756-283X",
publisher = "SAGE Publications Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Enteroendocrine cells

T2 - neglected players in gastrointestinal disorders?

AU - Moran, Gordon W.

AU - Leslie, Fiona C.

AU - Levison, Scott E.

AU - Worthington, J

AU - McLaughlin, John T.

PY - 2008/7

Y1 - 2008/7

N2 - Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body. They secrete multiple regulatory molecules which control physiological and homeostatic functions, particularly postprandial secretion and motility. Their key purpose is to act as sensors of luminal contents, either in a classical endocrine fashion, or by a paracrine effect on proximate cells, notably vagal afferent fibres. They also play a pivotal role in the control of food intake, and emerging data add roles in mucosal immunity and repair. We propose that EEC are fundamental in several gastrointestinal pathologies, notably Post-infectious Irritable Bowel Syndrome, infectious enteritis, and possibly inflammatory bowel disease. Further work is needed to fully illustrate the importance, detailed biology and therapeutic potential of these frequently overlooked cells.

AB - Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body. They secrete multiple regulatory molecules which control physiological and homeostatic functions, particularly postprandial secretion and motility. Their key purpose is to act as sensors of luminal contents, either in a classical endocrine fashion, or by a paracrine effect on proximate cells, notably vagal afferent fibres. They also play a pivotal role in the control of food intake, and emerging data add roles in mucosal immunity and repair. We propose that EEC are fundamental in several gastrointestinal pathologies, notably Post-infectious Irritable Bowel Syndrome, infectious enteritis, and possibly inflammatory bowel disease. Further work is needed to fully illustrate the importance, detailed biology and therapeutic potential of these frequently overlooked cells.

KW - Enteroendocrine cells

KW - innate immunity

KW - inflammation

KW - inflammatory bowel disease

KW - irritable bowel syndrome

KW - anendocrinosis

U2 - 10.1177/1756283X08093943

DO - 10.1177/1756283X08093943

M3 - Journal article

C2 - 21180514

VL - 1

SP - 51

EP - 60

JO - Therapeutic Advances in Gastroenterology

JF - Therapeutic Advances in Gastroenterology

SN - 1756-283X

IS - 1

ER -