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  • Laura O’Donovan, Nicola Jane Williams, and Stephen Wilkinson (11 April 2019)

    Submitted manuscript, 627 KB, PDF document

  • O_Donovan_Williams_Wilkinson_FINAL_RESUBMISSION_06_June_2019_

    Accepted author manuscript, 240 KB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

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Ethical and Policy Issues Raised by Uterus Transplants

Research output: Contribution to journalJournal article

Published
<mark>Journal publication date</mark>2/09/2019
<mark>Journal</mark>British Medical Bulletin
Issue number1
Volume131
Number of pages10
Pages (from-to)19-28
Publication statusPublished
Early online date27/08/19
Original languageEnglish

Abstract

Introduction: In 2014, Brännström and colleagues reported the first human live birth following uterine transplantation (UTx). Research into this treatment for absolute uterine factor infertility has since grown with clinical trials currently taking place across centers in at least thirteen countries worldwide.

Sources of data: This review summarizes and critiques the academic literature on ethical and policy issues raised by UTx.

Areas of agreement: There is general agreement on the importance of risk reduction and, in principle, to the sharing and maintenance of patient data on an international registry.

Areas of controversy: There are numerous areas of controversy ranging from whether it is ethically justified to carry out uterus transplants at all (considering the associated health risks) to how deceased donor organs for transplant should be allocated. This review focuses on three key issues: the choice between deceased and living donors, ensuring valid consent to the procedure and access to treatment.

Growing points; UTx is presently a novel and rare procedure but is likely to become more commonplace in the foreseeable future, given the large number of surgical teams working on it worldwide.

Areas timely for developing research: Uterus transplantation requires us to re-examine fundamental questions about the ethical and social value of gestation. If eventually extended to transgender women or even to men, it may also require us to reconceptualize what it is to be a ‘father’ or to be a ‘mother’, and the definition of these terms in law.