Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Eukaryotic flagella
T2 - variations in form, function, and composition during evolution
AU - Moran, Jonathan
AU - McKean, Paul
AU - Ginger, Michael
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture—the classic microtubule configuration seen in most axonemes—belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.
AB - The microtubule axoneme is an iconic structure in eukaryotic cell biology and the defining structure in all eukaryotic flagella (or cilia). Flagella occur in taxa spanning the breadth of eukaryotic evolution, which indicates that the organelle's origin predates the radiation of extant eukaryotes from a last common ancestor. During evolution, the flagellar architecture has been subject to both elaboration and moderation. Even conservation of 9+2 architecture—the classic microtubule configuration seen in most axonemes—belies surprising variation in protein content. Classically considered as organelles of motility that support cell swimming or fast movement of material across a cell surface, it is now clear that the functions of flagella are also far broader; for instance, the involvement of flagella in sensory perception and protein secretion has recently been made evident in both protists and animals. Here, we review and discuss, in an evolutionary context, recent advances in our understanding of flagellum function and composition.
KW - Chlamydomonas
KW - centriole
KW - cell biology
KW - microtubules
KW - Trypanosoma
U2 - 10.1093/biosci/biu175
DO - 10.1093/biosci/biu175
M3 - Journal article
VL - 64
SP - 1103
EP - 1114
JO - Bioscience
JF - Bioscience
SN - 0006-3568
IS - 12
ER -