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Evidence from Raman spectroscopy of a putative link between inherent bone matrix chemistry and degenerative joint disease

Research output: Contribution to journalJournal article

Published
  • Jemma G. Kerns
  • Panagiotis D. Gikas
  • Kevin Buckley
  • Adam Shepperd
  • Helen L. Birch
  • Ian McCarthy
  • Jonathan Miles
  • Timothy W. R. Briggs
  • Richard Keen
  • Anthony W. Parker
  • Pavel Matousek
  • Allen E. Goodship
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<mark>Journal publication date</mark>05/2014
<mark>Journal</mark>Arthritis and Rheumatology
Issue number5
Volume66
Number of pages10
Pages (from-to)1237-1246
Publication statusPublished
Original languageEnglish

Abstract

Osteoarthritis (OA) is a common debilitating disease that results in degeneration of cartilage and bone in the synovial joints. Subtle changes in the molecular structure of the subchondral bone matrix occur and may be associated with cartilage changes. The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.

Bibliographic note

© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.