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Expedient approach to chiral cyclobutanones: asymmetric synthesis of cyclobut-G

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<mark>Journal publication date</mark>6/03/2008
<mark>Journal</mark>Organic Letters
Issue number5
Volume10
Number of pages4
Pages (from-to)821-824
Publication statusPublished
Original languageEnglish

Abstract

An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.