The prefabricated residential buildings have become one of the most dominating construction methods in the modern construction industry. The seismic behavior of prefabricated components is crucial in the limit state design of the precast structure. This paper investigates the seismic behavior of a new type precast concrete column that has clustered steel reinforcement with grouting connection. Quasi-static tests are carried out on three cast-in-situ columns and seven precast columns. Axial compression ratio, lap length and lap space are the main variables considered. The failure process, hysteresis curve, skeleton curve, stiffness degradation, displacement ductility and energy dissipation are elaborated. The experimental results show that the precast columns with cluster reinforcement have similar seismic behavior to the cast-in-situ columns. Reducing the axial pressure can improve the ductility and energy consumption performance of the cluster-reinforced columns and exert its ductility to improve its seismic performance. During the assembly, a moderate increase in lap length can improve the seismic behavior of precast columns, whereas the lap space has an insignificant effect on the seismic behavior which indicates that the lap space is not an important factor during construction. The research outcome can serve as a reference for further development and application of precast structures.