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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

Research output: Contribution to journalJournal article

Published
  • D. J. Clancy
  • D. Gems
  • L. G. Harshman
  • S. Oldham
  • H. Stocker
  • E. Hafen
  • S. J. Leevers
  • L. Partridge
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<mark>Journal publication date</mark>6/04/2001
<mark>Journal</mark>Science
Issue number5514
Volume292
Number of pages3
Pages (from-to)104-106
Publication statusPublished
Original languageEnglish

Abstract

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

Bibliographic note

Apr 6 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein