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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. / Clancy, D. J.; Gems, D.; Harshman, L. G. et al.
In: Science, Vol. 292, No. 5514, 06.04.2001, p. 104-106.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Clancy, DJ, Gems, D, Harshman, LG, Oldham, S, Stocker, H, Hafen, E, Leevers, SJ & Partridge, L 2001, 'Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein', Science, vol. 292, no. 5514, pp. 104-106. https://doi.org/10.1126/science.1057991

APA

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science, 292(5514), 104-106. https://doi.org/10.1126/science.1057991

Vancouver

Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 2001 Apr 6;292(5514):104-106. doi: 10.1126/science.1057991

Author

Clancy, D. J. ; Gems, D. ; Harshman, L. G. et al. / Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. In: Science. 2001 ; Vol. 292, No. 5514. pp. 104-106.

Bibtex

@article{b57bb98d52524f75b1201df934f4f7ea,
title = "Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein",
abstract = "The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.",
author = "Clancy, {D. J.} and D. Gems and Harshman, {L. G.} and S. Oldham and H. Stocker and E. Hafen and Leevers, {S. J.} and L. Partridge",
note = "Apr 6 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein",
year = "2001",
month = apr,
day = "6",
doi = "10.1126/science.1057991",
language = "English",
volume = "292",
pages = "104--106",
journal = "Science",
publisher = "American Association for the Advancement of Science",
number = "5514",

}

RIS

TY - JOUR

T1 - Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

AU - Clancy, D. J.

AU - Gems, D.

AU - Harshman, L. G.

AU - Oldham, S.

AU - Stocker, H.

AU - Hafen, E.

AU - Leevers, S. J.

AU - Partridge, L.

N1 - Apr 6 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

PY - 2001/4/6

Y1 - 2001/4/6

N2 - The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

AB - The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

U2 - 10.1126/science.1057991

DO - 10.1126/science.1057991

M3 - Journal article

VL - 292

SP - 104

EP - 106

JO - Science

JF - Science

IS - 5514

ER -