Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes. / Robinson, Nicholas P.; Bell, Stephen D.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 14, 03.04.2007, p. 5806-5811.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Robinson, NP & Bell, SD 2007, 'Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 14, pp. 5806-5811. https://doi.org/10.1073/pnas.0700206104

APA

Robinson, N. P., & Bell, S. D. (2007). Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes. Proceedings of the National Academy of Sciences of the United States of America, 104(14), 5806-5811. https://doi.org/10.1073/pnas.0700206104

Vancouver

Robinson NP, Bell SD. Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 2007 Apr 3;104(14):5806-5811. doi: 10.1073/pnas.0700206104

Author

Robinson, Nicholas P. ; Bell, Stephen D. / Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 14. pp. 5806-5811.

Bibtex

@article{e22afdb3c0bb4a649d4e436a92b542a3,

title = "Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes",

abstract = "In all three domains of life, DNA replication begins at specialized loci termed replication origins. In bacteria, replication initiates from a single, clearly defined site. In contrast, eukaryotic organisms exploit a multitude of replication origins, dividing their genomes into an array of short contiguous units. Recently, the multiple replication origin paradigm has also been demonstrated within the archaeal domain of life, with the discovery that the hyperthermophilic archaeon Sulfolobus has three replication origins. However, the evolutionary mechanism driving the progression from single to multiple origin usage remains unclear. Here, we demonstrate that Aeropyrum pernix, a distant relative of Sulfolobus, has two origins. Comparison with the Sulfolobus origins provides evidence for evolution of replicon complexity by capture of extrachromosomal genetic elements. We additionally identify a previously unrecognized candidate archaeal initiator protein that is distantly related to eukaryotic Cdt1. Our data thus provide evidence that horizontal gene transfer, in addition to its well-established role in contributing to the information content of chromosomes, may fundamentally alter the manner in which the host chromosome is replicated.",

keywords = "Aeropyrum, Amino Acid Sequence, Archaeal Proteins, Base Sequence, Cell Cycle Proteins, Chromosomes, Archaeal, DNA Footprinting, DNA Replication, DNA-Binding Proteins, Evolution, Molecular, Extrachromosomal Inheritance, Genes, Archaeal, Molecular Sequence Data, Open Reading Frames, Origin Recognition Complex, Protein Structure, Tertiary, Replication Origin, Replicon, Restriction Mapping, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Sulfolobus acidocaldarius, Sulfolobus solfataricus, Comparative Study, Journal Article",

author = "Robinson, {Nicholas P.} and Bell, {Stephen D.}",

year = "2007",

month = apr,

day = "3",

doi = "10.1073/pnas.0700206104",

language = "English",

volume = "104",

pages = "5806--5811",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "14",

}

RIS

TY - JOUR

T1 - Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes

AU - Robinson, Nicholas P.

AU - Bell, Stephen D.

PY - 2007/4/3

Y1 - 2007/4/3

N2 - In all three domains of life, DNA replication begins at specialized loci termed replication origins. In bacteria, replication initiates from a single, clearly defined site. In contrast, eukaryotic organisms exploit a multitude of replication origins, dividing their genomes into an array of short contiguous units. Recently, the multiple replication origin paradigm has also been demonstrated within the archaeal domain of life, with the discovery that the hyperthermophilic archaeon Sulfolobus has three replication origins. However, the evolutionary mechanism driving the progression from single to multiple origin usage remains unclear. Here, we demonstrate that Aeropyrum pernix, a distant relative of Sulfolobus, has two origins. Comparison with the Sulfolobus origins provides evidence for evolution of replicon complexity by capture of extrachromosomal genetic elements. We additionally identify a previously unrecognized candidate archaeal initiator protein that is distantly related to eukaryotic Cdt1. Our data thus provide evidence that horizontal gene transfer, in addition to its well-established role in contributing to the information content of chromosomes, may fundamentally alter the manner in which the host chromosome is replicated.

AB - In all three domains of life, DNA replication begins at specialized loci termed replication origins. In bacteria, replication initiates from a single, clearly defined site. In contrast, eukaryotic organisms exploit a multitude of replication origins, dividing their genomes into an array of short contiguous units. Recently, the multiple replication origin paradigm has also been demonstrated within the archaeal domain of life, with the discovery that the hyperthermophilic archaeon Sulfolobus has three replication origins. However, the evolutionary mechanism driving the progression from single to multiple origin usage remains unclear. Here, we demonstrate that Aeropyrum pernix, a distant relative of Sulfolobus, has two origins. Comparison with the Sulfolobus origins provides evidence for evolution of replicon complexity by capture of extrachromosomal genetic elements. We additionally identify a previously unrecognized candidate archaeal initiator protein that is distantly related to eukaryotic Cdt1. Our data thus provide evidence that horizontal gene transfer, in addition to its well-established role in contributing to the information content of chromosomes, may fundamentally alter the manner in which the host chromosome is replicated.

KW - Aeropyrum

KW - Amino Acid Sequence

KW - Archaeal Proteins

KW - Base Sequence

KW - Cell Cycle Proteins

KW - Chromosomes, Archaeal

KW - DNA Footprinting

KW - DNA Replication

KW - DNA-Binding Proteins

KW - Evolution, Molecular

KW - Extrachromosomal Inheritance

KW - Genes, Archaeal

KW - Molecular Sequence Data

KW - Open Reading Frames

KW - Origin Recognition Complex

KW - Protein Structure, Tertiary

KW - Replication Origin

KW - Replicon

KW - Restriction Mapping

KW - Saccharomyces cerevisiae Proteins

KW - Sequence Homology, Amino Acid

KW - Sequence Homology, Nucleic Acid

KW - Sulfolobus acidocaldarius

KW - Sulfolobus solfataricus

KW - Comparative Study

KW - Journal Article

U2 - 10.1073/pnas.0700206104

DO - 10.1073/pnas.0700206104

M3 - Journal article

C2 - 17392430

VL - 104

SP - 5806

EP - 5811

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 14

ER -

Research

Links

Text available via DOI:

Keywords