Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle. / Claridge, Jen; Diggle, Peter; McCann, Catherine et al.
In: Nature Communications, Vol. 3, No. n/a, 853, 2012.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Claridge, J, Diggle, P, McCann, C, Mulcahy, G, Flynn, R, McNair, J, Strain, S, Welsh, M, Baylis, M & Williams, DJL 2012, 'Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle', Nature Communications, vol. 3, no. n/a, 853. https://doi.org/10.1038/ncomms1840

APA

Claridge, J., Diggle, P., McCann, C., Mulcahy, G., Flynn, R., McNair, J., Strain, S., Welsh, M., Baylis, M., & Williams, D. J. L. (2012). Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle. Nature Communications, 3(n/a), Article 853. https://doi.org/10.1038/ncomms1840

Vancouver

Claridge J, Diggle P, McCann C, Mulcahy G, Flynn R, McNair J et al. Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle. Nature Communications. 2012;3(n/a):853. Epub 2012 May 22. doi: 10.1038/ncomms1840

Author

Claridge, Jen ; Diggle, Peter ; McCann, Catherine et al. / Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle. In: Nature Communications. 2012 ; Vol. 3, No. n/a.

Bibtex

@article{f22bc97cfc72481fbc83d6a2186d8131,

title = "Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle",

abstract = "Bovine tuberculosis (BTB) is a significant and intractable disease of cattle caused by Mycobacterium bovis. In the United Kingdom, despite an aggressive eradication programme, the prevalence of BTB is increasing with an unexplained, exponential rise in cases year on year. Here we show in a study involving 3,026 dairy herds in England and Wales that there is a significant negative association between exposure to the common, ubiquitous helminth parasite, Fasciola hepatica and diagnosis of BTB. The magnitude of the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattle experimentally co-infected with M. bovis and F. hepatica. We estimate an under-ascertainment rate of about one-third (95% confidence interval 27–38%) among our study farms, in the hypothetical situation of no exposure to F. hepatica. This finding may in part explain the continuing spread of BTB and the failure of the current eradication programme in the United Kingdom.",

keywords = "biological sciences, immunology, microbiology",

author = "Jen Claridge and Peter Diggle and Catherine McCann and Grace Mulcahy and Rob Flynn and Jim McNair and Sam Strain and Michael Welsh and Matthew Baylis and Williams, {Diana J.L.}",

year = "2012",

doi = "10.1038/ncomms1840",

language = "English",

volume = "3",

journal = "Nature Communications",

publisher = "Nature Publishing Group",

number = "n/a",

}

RIS

TY - JOUR

T1 - Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle

AU - Claridge, Jen

AU - Diggle, Peter

AU - McCann, Catherine

AU - Mulcahy, Grace

AU - Flynn, Rob

AU - McNair, Jim

AU - Strain, Sam

AU - Welsh, Michael

AU - Baylis, Matthew

AU - Williams, Diana J.L.

PY - 2012

Y1 - 2012

N2 - Bovine tuberculosis (BTB) is a significant and intractable disease of cattle caused by Mycobacterium bovis. In the United Kingdom, despite an aggressive eradication programme, the prevalence of BTB is increasing with an unexplained, exponential rise in cases year on year. Here we show in a study involving 3,026 dairy herds in England and Wales that there is a significant negative association between exposure to the common, ubiquitous helminth parasite, Fasciola hepatica and diagnosis of BTB. The magnitude of the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattle experimentally co-infected with M. bovis and F. hepatica. We estimate an under-ascertainment rate of about one-third (95% confidence interval 27–38%) among our study farms, in the hypothetical situation of no exposure to F. hepatica. This finding may in part explain the continuing spread of BTB and the failure of the current eradication programme in the United Kingdom.

AB - Bovine tuberculosis (BTB) is a significant and intractable disease of cattle caused by Mycobacterium bovis. In the United Kingdom, despite an aggressive eradication programme, the prevalence of BTB is increasing with an unexplained, exponential rise in cases year on year. Here we show in a study involving 3,026 dairy herds in England and Wales that there is a significant negative association between exposure to the common, ubiquitous helminth parasite, Fasciola hepatica and diagnosis of BTB. The magnitude of the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattle experimentally co-infected with M. bovis and F. hepatica. We estimate an under-ascertainment rate of about one-third (95% confidence interval 27–38%) among our study farms, in the hypothetical situation of no exposure to F. hepatica. This finding may in part explain the continuing spread of BTB and the failure of the current eradication programme in the United Kingdom.

KW - biological sciences

KW - immunology

KW - microbiology

UR - http://www.scopus.com/inward/record.url?scp=84862619219&partnerID=8YFLogxK

U2 - 10.1038/ncomms1840

DO - 10.1038/ncomms1840

M3 - Journal article

AN - SCOPUS:84862619219

VL - 3

JO - Nature Communications

JF - Nature Communications

IS - n/a

M1 - 853

ER -

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