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    Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Affective Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Affective Disorders, 256, 2020 DOI: 10.1016/j.jad.2019.05.038

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Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use: A single blind randomised controlled trial

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Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use : A single blind randomised controlled trial. / Jones, Steven H; Riste, Lisa; Robinson, Heather; Holland, Fiona; Peters, Sarah; Hartwell, Rosalyn; Berry, Katherine; Fitzsimmons, Mike; Wilson, Ian; Hilton, Claire; Long, Rita; Bateman, Lucy; Weymouth, Emma; Owen, Rebecca; Roberts, Chris; Barrowclough, Christine.

In: Journal of Affective Disorders, Vol. 256, 01.09.2019, p. 86-95.

Research output: Contribution to journalJournal article

Harvard

Jones, SH, Riste, L, Robinson, H, Holland, F, Peters, S, Hartwell, R, Berry, K, Fitzsimmons, M, Wilson, I, Hilton, C, Long, R, Bateman, L, Weymouth, E, Owen, R, Roberts, C & Barrowclough, C 2019, 'Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use: A single blind randomised controlled trial', Journal of Affective Disorders, vol. 256, pp. 86-95. https://doi.org/10.1016/j.jad.2019.05.038

APA

Jones, S. H., Riste, L., Robinson, H., Holland, F., Peters, S., Hartwell, R., Berry, K., Fitzsimmons, M., Wilson, I., Hilton, C., Long, R., Bateman, L., Weymouth, E., Owen, R., Roberts, C., & Barrowclough, C. (2019). Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use: A single blind randomised controlled trial. Journal of Affective Disorders, 256, 86-95. https://doi.org/10.1016/j.jad.2019.05.038

Vancouver

Author

Jones, Steven H ; Riste, Lisa ; Robinson, Heather ; Holland, Fiona ; Peters, Sarah ; Hartwell, Rosalyn ; Berry, Katherine ; Fitzsimmons, Mike ; Wilson, Ian ; Hilton, Claire ; Long, Rita ; Bateman, Lucy ; Weymouth, Emma ; Owen, Rebecca ; Roberts, Chris ; Barrowclough, Christine. / Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use : A single blind randomised controlled trial. In: Journal of Affective Disorders. 2019 ; Vol. 256. pp. 86-95.

Bibtex

@article{2e66290353824274849f10083b12e212,
title = "Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use: A single blind randomised controlled trial",
abstract = "Background Alcohol use is a common problem in bipolar disorder (BD) and evidence indicates more promising outcomes for alcohol use than other substances. No trials have evaluated individual integrated motivational interviewing and cognitive behaviour therapy (MI-CBT) for problematic alcohol use in BD. We therefore assessed the feasibility and acceptability of a novel MI-CBT intervention for alcohol use in BD. Methods A single blind RCT was conducted to compare MI-CBT plus treatment as usual (TAU) with TAU only. MI-CBT was delivered over 20 sessions with participants followed up at 3, 6, 9 and 12 months post-randomisation. Primary outcomes were the feasibility and acceptability of MI-CBT (recruitment to target, retention to follow-up and therapy, acceptability of therapy and absence of adverse events). We also conducted preliminary analyses of alcohol and mood outcomes (frequency and severity of alcohol use and time to mood relapse). Results 44 participants were recruited with 75% retention to 6 and 12 months follow-up. Therapy participants attended a mean of 17.6 (SD 4.5) sessions. Therapy alliance and treatment fidelity were acceptable. Qualitative interviews indicated the intervention was experienced as collaborative, and helpful, in addressing mood and alcohol issues, although risk of overconfidence following therapy was also identified. Clinical outcomes did not differ between arms at 12 months follow-up. Limitations As a feasibility and acceptability trial any secondary results should be treated with caution. Conclusions Integrated MI-CBT is feasible and acceptable, but lack of clinical impact, albeit in a feasibility study, suggests need for further development. Potential adaptations are discussed.",
keywords = "Bipolar disorder, Alcohol, Substance, Motivational interviewing, Randomised controlled trial, Feasibility study",
author = "Jones, {Steven H} and Lisa Riste and Heather Robinson and Fiona Holland and Sarah Peters and Rosalyn Hartwell and Katherine Berry and Mike Fitzsimmons and Ian Wilson and Claire Hilton and Rita Long and Lucy Bateman and Emma Weymouth and Rebecca Owen and Chris Roberts and Christine Barrowclough",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Journal of Affective Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Affective Disorders, 256, 2020 DOI: 10.1016/j.jad.2019.05.038",
year = "2019",
month = sep,
day = "1",
doi = "10.1016/j.jad.2019.05.038",
language = "English",
volume = "256",
pages = "86--95",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Feasibility and acceptability of integrated psychological therapy versus treatment as usual for people with bipolar disorder and co-morbid alcohol use

T2 - A single blind randomised controlled trial

AU - Jones, Steven H

AU - Riste, Lisa

AU - Robinson, Heather

AU - Holland, Fiona

AU - Peters, Sarah

AU - Hartwell, Rosalyn

AU - Berry, Katherine

AU - Fitzsimmons, Mike

AU - Wilson, Ian

AU - Hilton, Claire

AU - Long, Rita

AU - Bateman, Lucy

AU - Weymouth, Emma

AU - Owen, Rebecca

AU - Roberts, Chris

AU - Barrowclough, Christine

N1 - This is the author’s version of a work that was accepted for publication in Journal of Affective Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Affective Disorders, 256, 2020 DOI: 10.1016/j.jad.2019.05.038

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background Alcohol use is a common problem in bipolar disorder (BD) and evidence indicates more promising outcomes for alcohol use than other substances. No trials have evaluated individual integrated motivational interviewing and cognitive behaviour therapy (MI-CBT) for problematic alcohol use in BD. We therefore assessed the feasibility and acceptability of a novel MI-CBT intervention for alcohol use in BD. Methods A single blind RCT was conducted to compare MI-CBT plus treatment as usual (TAU) with TAU only. MI-CBT was delivered over 20 sessions with participants followed up at 3, 6, 9 and 12 months post-randomisation. Primary outcomes were the feasibility and acceptability of MI-CBT (recruitment to target, retention to follow-up and therapy, acceptability of therapy and absence of adverse events). We also conducted preliminary analyses of alcohol and mood outcomes (frequency and severity of alcohol use and time to mood relapse). Results 44 participants were recruited with 75% retention to 6 and 12 months follow-up. Therapy participants attended a mean of 17.6 (SD 4.5) sessions. Therapy alliance and treatment fidelity were acceptable. Qualitative interviews indicated the intervention was experienced as collaborative, and helpful, in addressing mood and alcohol issues, although risk of overconfidence following therapy was also identified. Clinical outcomes did not differ between arms at 12 months follow-up. Limitations As a feasibility and acceptability trial any secondary results should be treated with caution. Conclusions Integrated MI-CBT is feasible and acceptable, but lack of clinical impact, albeit in a feasibility study, suggests need for further development. Potential adaptations are discussed.

AB - Background Alcohol use is a common problem in bipolar disorder (BD) and evidence indicates more promising outcomes for alcohol use than other substances. No trials have evaluated individual integrated motivational interviewing and cognitive behaviour therapy (MI-CBT) for problematic alcohol use in BD. We therefore assessed the feasibility and acceptability of a novel MI-CBT intervention for alcohol use in BD. Methods A single blind RCT was conducted to compare MI-CBT plus treatment as usual (TAU) with TAU only. MI-CBT was delivered over 20 sessions with participants followed up at 3, 6, 9 and 12 months post-randomisation. Primary outcomes were the feasibility and acceptability of MI-CBT (recruitment to target, retention to follow-up and therapy, acceptability of therapy and absence of adverse events). We also conducted preliminary analyses of alcohol and mood outcomes (frequency and severity of alcohol use and time to mood relapse). Results 44 participants were recruited with 75% retention to 6 and 12 months follow-up. Therapy participants attended a mean of 17.6 (SD 4.5) sessions. Therapy alliance and treatment fidelity were acceptable. Qualitative interviews indicated the intervention was experienced as collaborative, and helpful, in addressing mood and alcohol issues, although risk of overconfidence following therapy was also identified. Clinical outcomes did not differ between arms at 12 months follow-up. Limitations As a feasibility and acceptability trial any secondary results should be treated with caution. Conclusions Integrated MI-CBT is feasible and acceptable, but lack of clinical impact, albeit in a feasibility study, suggests need for further development. Potential adaptations are discussed.

KW - Bipolar disorder

KW - Alcohol

KW - Substance

KW - Motivational interviewing

KW - Randomised controlled trial

KW - Feasibility study

U2 - 10.1016/j.jad.2019.05.038

DO - 10.1016/j.jad.2019.05.038

M3 - Journal article

VL - 256

SP - 86

EP - 95

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -