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  • journal.pntd.0003339

    Rights statement: © 2014 Pothirat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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First isolation of Leishmania from Northern Thailand: case report, identification as Leishmania martiniquensis and phylogenetic position within the Leishmania enriettii complex

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  • Thatawan Pothirat
  • Adisak Tantiworawit
  • Romanee Chaiwarith
  • Narissara Jariyapan
  • Anchalee Wannasan
  • Padet Siriyasatien
  • Khuanchai Supparatpinyo
  • Michelle D. Bates
  • Godwin Kwakye-Nuako
  • Paul A. Bates
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Article numbere3339
<mark>Journal publication date</mark>12/2014
<mark>Journal</mark>PLoS Neglected Tropical Diseases
Issue number12
Volume8
Number of pages8
Publication statusPublished
Original languageEnglish

Abstract

Since 1996, there have been several case reports of autochthonous visceral leishmaniasis in Thailand. Here we report a case in a 52-year-old Thai male from northern Thailand, who presented with subacute fever, huge splenomegaly and pancytopenia. Bone marrow aspiration revealed numerous amastigotes within macrophages. Isolation of Leishmania LSCM1 into culture and DNA sequence analysis (ribosomal RNA ITS-1 and large subunit of RNA polymerase II) revealed the parasites to be members of the Leishmania enriettii complex, and apparently identical to L. martiniquensis previously reported from the Caribbean island of Martinique. This is the first report of visceral leishmaniasis caused by L. martiniquensis from the region. Moreover, the majority of parasites previously identified as "L. siamensis" also appear to be L. martiniquensis.

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© 2014 Pothirat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.