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Fluctuations in a coupled-oscillator model of the cardiovascular system

Research output: Contribution to journalJournal article

Published

<mark>Journal publication date</mark>2007
<mark>Journal</mark>Proceedings of SPIE
Volume6602
Number of pages12
<mark>Original language</mark>English

Abstract

We present a model of the cardiovascular system (CVS) based on a system of coupled oscillators. Using this approach we can describe several complex physiological phenomena that can have a range of applications. For instance, heart rate variability (HRV), can have a new deterministic explanation. The intrinsic dynamics of the HRV is controlled by deterministic couplings between the physiological oscillators in our model and without the need to introduce external noise as is commonly done. This new result provides potential applications not only for physiological systems but also for the design of very precise electronic generators where the frequency stability is crucial. Another important phenomenon is that of oscillation death. We show that in our CVS model the mechanism leading to the quenching of the oscillations can be controlled, not only by the coupling parameter, but by a more general scheme. In fact, we propose that a change in the relative current state of the cardiovascular oscillators can lead to a cease of the oscillations without actually changing the strength of the coupling among them. We performed real experiments using electronic oscillators and show them to match the theoretical and numerical predictions. We discuss the relevance of the studied phenomena to real cardiovascular systems regimes, including the explanation of certain pathologies, and the possible applications in medical practice.

Bibliographic note

Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724718