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Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Research output: Contribution to journalJournal article

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  • Marcus Hill
  • Richard Cunningham
  • Rania Hathout
  • Christopher Johnston
  • John Hardy
  • Marie Migaud
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Article number26
<mark>Journal publication date</mark>13/06/2019
<mark>Journal</mark>Journal of Functional Biomaterials
Issue number2
Volume10
Number of pages14
Publication statusPublished
Original languageEnglish

Abstract

Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (Pseudomonas aeruginosa) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function.