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Frailty and chronic kidney disease: current evidence and continuing uncertainties

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Frailty and chronic kidney disease : current evidence and continuing uncertainties. / Nixon, Andrew C; Bampouras, Theodoros M; Pendleton, Neil; Woywodt, Alexander; Mitra, Sandip; Dhaygude, Ajay.

In: Clinical kidney journal, Vol. 11, No. 2, 04.2018, p. 236-245.

Research output: Contribution to journalJournal article

Harvard

Nixon, AC, Bampouras, TM, Pendleton, N, Woywodt, A, Mitra, S & Dhaygude, A 2018, 'Frailty and chronic kidney disease: current evidence and continuing uncertainties', Clinical kidney journal, vol. 11, no. 2, pp. 236-245. https://doi.org/10.1093/ckj/sfx134

APA

Nixon, A. C., Bampouras, T. M., Pendleton, N., Woywodt, A., Mitra, S., & Dhaygude, A. (2018). Frailty and chronic kidney disease: current evidence and continuing uncertainties. Clinical kidney journal, 11(2), 236-245. https://doi.org/10.1093/ckj/sfx134

Vancouver

Nixon AC, Bampouras TM, Pendleton N, Woywodt A, Mitra S, Dhaygude A. Frailty and chronic kidney disease: current evidence and continuing uncertainties. Clinical kidney journal. 2018 Apr;11(2):236-245. https://doi.org/10.1093/ckj/sfx134

Author

Nixon, Andrew C ; Bampouras, Theodoros M ; Pendleton, Neil ; Woywodt, Alexander ; Mitra, Sandip ; Dhaygude, Ajay. / Frailty and chronic kidney disease : current evidence and continuing uncertainties. In: Clinical kidney journal. 2018 ; Vol. 11, No. 2. pp. 236-245.

Bibtex

@article{ec81f86edf6245589a384a7502bba25a,
title = "Frailty and chronic kidney disease: current evidence and continuing uncertainties",
abstract = "Frailty, the state of increased vulnerability to physical stressors as a result of progressive and sustained degeneration in multiple physiological systems, is common in those with chronic kidney disease (CKD). In fact, the prevalence of frailty in the older adult population is reported to be 11{\%}, whereas the prevalence of frailty has been reported to be greater than 60{\%} in dialysis-dependent CKD patients. Frailty is independently linked with adverse clinical outcomes in all stages of CKD and has been repeatedly shown to be associated with an increased risk of mortality and hospitalization. In recent years there have been efforts to create an operationalized definition of frailty to aid its diagnosis and to categorize its severity. Two principal concepts are described, namely the Fried Phenotype Model of Physical Frailty and the Cumulative Deficit Model of Frailty. There is no agreement on which frailty assessment approach is superior, therefore, for the time being, emphasis should be placed on any efforts to identify frailty. Recognizing frailty should prompt a holistic assessment of the patient to address risk factors that may exacerbate its progression and to ensure that the patient has appropriate psychological and social support. Adequate nutritional intake is essential and individualized exercise programmes should be offered. The acknowledgement of frailty should prompt discussions that explore the future care wishes of these vulnerable patients. With further study, nephrologists may be able to use frailty assessments to inform discussions with patients about the initiation of renal replacement therapy.",
keywords = "Journal Article",
author = "Nixon, {Andrew C} and Bampouras, {Theodoros M} and Neil Pendleton and Alexander Woywodt and Sandip Mitra and Ajay Dhaygude",
year = "2018",
month = "4",
doi = "10.1093/ckj/sfx134",
language = "English",
volume = "11",
pages = "236--245",
journal = "Clinical kidney journal",
issn = "2048-8505",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Frailty and chronic kidney disease

T2 - current evidence and continuing uncertainties

AU - Nixon, Andrew C

AU - Bampouras, Theodoros M

AU - Pendleton, Neil

AU - Woywodt, Alexander

AU - Mitra, Sandip

AU - Dhaygude, Ajay

PY - 2018/4

Y1 - 2018/4

N2 - Frailty, the state of increased vulnerability to physical stressors as a result of progressive and sustained degeneration in multiple physiological systems, is common in those with chronic kidney disease (CKD). In fact, the prevalence of frailty in the older adult population is reported to be 11%, whereas the prevalence of frailty has been reported to be greater than 60% in dialysis-dependent CKD patients. Frailty is independently linked with adverse clinical outcomes in all stages of CKD and has been repeatedly shown to be associated with an increased risk of mortality and hospitalization. In recent years there have been efforts to create an operationalized definition of frailty to aid its diagnosis and to categorize its severity. Two principal concepts are described, namely the Fried Phenotype Model of Physical Frailty and the Cumulative Deficit Model of Frailty. There is no agreement on which frailty assessment approach is superior, therefore, for the time being, emphasis should be placed on any efforts to identify frailty. Recognizing frailty should prompt a holistic assessment of the patient to address risk factors that may exacerbate its progression and to ensure that the patient has appropriate psychological and social support. Adequate nutritional intake is essential and individualized exercise programmes should be offered. The acknowledgement of frailty should prompt discussions that explore the future care wishes of these vulnerable patients. With further study, nephrologists may be able to use frailty assessments to inform discussions with patients about the initiation of renal replacement therapy.

AB - Frailty, the state of increased vulnerability to physical stressors as a result of progressive and sustained degeneration in multiple physiological systems, is common in those with chronic kidney disease (CKD). In fact, the prevalence of frailty in the older adult population is reported to be 11%, whereas the prevalence of frailty has been reported to be greater than 60% in dialysis-dependent CKD patients. Frailty is independently linked with adverse clinical outcomes in all stages of CKD and has been repeatedly shown to be associated with an increased risk of mortality and hospitalization. In recent years there have been efforts to create an operationalized definition of frailty to aid its diagnosis and to categorize its severity. Two principal concepts are described, namely the Fried Phenotype Model of Physical Frailty and the Cumulative Deficit Model of Frailty. There is no agreement on which frailty assessment approach is superior, therefore, for the time being, emphasis should be placed on any efforts to identify frailty. Recognizing frailty should prompt a holistic assessment of the patient to address risk factors that may exacerbate its progression and to ensure that the patient has appropriate psychological and social support. Adequate nutritional intake is essential and individualized exercise programmes should be offered. The acknowledgement of frailty should prompt discussions that explore the future care wishes of these vulnerable patients. With further study, nephrologists may be able to use frailty assessments to inform discussions with patients about the initiation of renal replacement therapy.

KW - Journal Article

U2 - 10.1093/ckj/sfx134

DO - 10.1093/ckj/sfx134

M3 - Journal article

C2 - 29644065

VL - 11

SP - 236

EP - 245

JO - Clinical kidney journal

JF - Clinical kidney journal

SN - 2048-8505

IS - 2

ER -