This paper presents arguments for recognising and tackling Hepatitis C (HCV) as a major challenge for social work. Despite repeated warnings from a variety of sources and thousands of new infections each year, successive governments have failed to address a public health emergency of immense proportions—the HCV epidemic. The implications for social work are significant. Social care workers, particularly those working with physically disabled adults or older adults, will find themselves with vastly increased caseloads as HCV diagnoses increase. This will necessitate them being able to adequately support families in a non-judgemental and non-stigmatising manner, which will mean a significant expansion of training and awareness-raising among professionals, in addition to strong inter-agency links and a transparent integrated care pathway.