Home > Research > Publications & Outputs > Genome-wide association study of borderline per...

Links

Text available via DOI:

View graph of relations

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. / Schizophrenia Working Group of the Psychiatric Genomics Consortium; Bipolar Disorders Working Group of the Psychiatric Genomics Consortium.
In: Translational Psychiatry, Vol. 7, No. 6, e1155, 20.06.2017.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Schizophrenia Working Group of the Psychiatric Genomics Consortium & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium 2017, 'Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia', Translational Psychiatry, vol. 7, no. 6, e1155. https://doi.org/10.1038/tp.2017.115

APA

Schizophrenia Working Group of the Psychiatric Genomics Consortium, & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational Psychiatry, 7(6), Article e1155. https://doi.org/10.1038/tp.2017.115

Vancouver

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational Psychiatry. 2017 Jun 20;7(6):e1155. doi: 10.1038/tp.2017.115

Author

Schizophrenia Working Group of the Psychiatric Genomics Consortium ; Bipolar Disorders Working Group of the Psychiatric Genomics Consortium. / Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. In: Translational Psychiatry. 2017 ; Vol. 7, No. 6.

Bibtex

@article{5e9a84f2a4fa4740b6477075038bb621,
title = "Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia",
abstract = "Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.",
keywords = "Adolescent, Adult, Aged, Bipolar Disorder, Borderline Personality Disorder, Case-Control Studies, Depressive Disorder, Major, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Multifactorial Inheritance, Schizophrenia, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "{Schizophrenia Working Group of the Psychiatric Genomics Consortium} and Witt, {S H} and F Streit and M Jungkunz and J Frank and S Awasthi and Reinbold, {C S} and J Treutlein and F Degenhardt and Forstner, {A J} and S Heilmann-Heimbach and L Dietl and Schwarze, {C E} and D Schendel and J Strohmaier and A Abdellaoui and R Adolfsson and Air, {T M} and H Akil and M Alda and N Alliey-Rodriguez and Andreassen, {O A} and G Babadjanova and Bass, {N J} and M Bauer and Baune, {B T} and F Bellivier and S Bergen and A Bethell and Biernacka, {J M} and Blackwood, {D H R} and Boks, {M P} and Boomsma, {D I} and B{\o}rglum, {A D} and M Borrmann-Hassenbach and P Brennan and M Budde and Buttensch{\o}n, {H N} and Byrne, {E M} and P Cervantes and T-K Clarke and N Craddock and C Cruceanu and D Curtis and I Jones and Jones, {L A} and McIntosh, {A M} and L Scott and Vincent, {J B} and Witt, {C C} and Jo Knight and {Bipolar Disorders Working Group of the Psychiatric Genomics Consortium}",
year = "2017",
month = jun,
day = "20",
doi = "10.1038/tp.2017.115",
language = "English",
volume = "7",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium

AU - Witt, S H

AU - Streit, F

AU - Jungkunz, M

AU - Frank, J

AU - Awasthi, S

AU - Reinbold, C S

AU - Treutlein, J

AU - Degenhardt, F

AU - Forstner, A J

AU - Heilmann-Heimbach, S

AU - Dietl, L

AU - Schwarze, C E

AU - Schendel, D

AU - Strohmaier, J

AU - Abdellaoui, A

AU - Adolfsson, R

AU - Air, T M

AU - Akil, H

AU - Alda, M

AU - Alliey-Rodriguez, N

AU - Andreassen, O A

AU - Babadjanova, G

AU - Bass, N J

AU - Bauer, M

AU - Baune, B T

AU - Bellivier, F

AU - Bergen, S

AU - Bethell, A

AU - Biernacka, J M

AU - Blackwood, D H R

AU - Boks, M P

AU - Boomsma, D I

AU - Børglum, A D

AU - Borrmann-Hassenbach, M

AU - Brennan, P

AU - Budde, M

AU - Buttenschøn, H N

AU - Byrne, E M

AU - Cervantes, P

AU - Clarke, T-K

AU - Craddock, N

AU - Cruceanu, C

AU - Curtis, D

AU - Jones, I

AU - Jones, L A

AU - McIntosh, A M

AU - Scott, L

AU - Vincent, J B

AU - Witt, C C

AU - Knight, Jo

AU - Bipolar Disorders Working Group of the Psychiatric Genomics Consortium

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.

AB - Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.

KW - Adolescent

KW - Adult

KW - Aged

KW - Bipolar Disorder

KW - Borderline Personality Disorder

KW - Case-Control Studies

KW - Depressive Disorder, Major

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Multifactorial Inheritance

KW - Schizophrenia

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/tp.2017.115

DO - 10.1038/tp.2017.115

M3 - Journal article

C2 - 28632202

VL - 7

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 6

M1 - e1155

ER -