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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.

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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. / Yeager, Meredith; Orr, Nick; Hayes, Richard B. et al.
In: Nature Genetics, Vol. 39, No. 5, 05.2007, p. 645-649.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Yeager, M, Orr, N, Hayes, RB, Jacobs, KB, Kraft, P, Wacholder, S, Minichiello, MJ, Fearnhead, P, Kai, Y, Chatterjee, N, Zhaoming, W, Welch, R, Staats, BJ, Calle, EE, Spencer-Fiegelsen, H, Thun, MJ, Rodriguez, C, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, FR, Giovannucci, E, Willett, WC, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, GL, Gelmann, EP, Tucker, M, Gerhard, DS, Fraumeni, JF, Hoover, R, Hunter, DJ, Chanock, SJ & Thomas, G 2007, 'Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.', Nature Genetics, vol. 39, no. 5, pp. 645-649. https://doi.org/10.1038/ng2022

APA

Yeager, M., Orr, N., Hayes, R. B., Jacobs, K. B., Kraft, P., Wacholder, S., Minichiello, M. J., Fearnhead, P., Kai, Y., Chatterjee, N., Zhaoming, W., Welch, R., Staats, B. J., Calle, E. E., Spencer-Fiegelsen, H., Thun, M. J., Rodriguez, C., Albanes, D., Virtamo, J., ... Thomas, G. (2007). Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nature Genetics, 39(5), 645-649. https://doi.org/10.1038/ng2022

Vancouver

Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nature Genetics. 2007 May;39(5):645-649. doi: 10.1038/ng2022

Author

Yeager, Meredith ; Orr, Nick ; Hayes, Richard B. et al. / Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. In: Nature Genetics. 2007 ; Vol. 39, No. 5. pp. 645-649.

Bibtex

@article{abbef771d26040f58889944fba1771a9,
title = "Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.",
abstract = "Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 times 10-13; heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13–1.41; homozygote OR: 1.58, 95% c.i.: 1.40–1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 P = 1.41 times 10-11; rs6983267 P = 6.62 times 10-10). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%).",
author = "Meredith Yeager and Nick Orr and Hayes, {Richard B.} and Jacobs, {Kevin B.} and Peter Kraft and Sholom Wacholder and Minichiello, {Mark J.} and Paul Fearnhead and Yu Kai and Nilanjan Chatterjee and Wang Zhaoming and Robert Welch and Staats, {Brian J.} and Calle, {Eugenia E.} and Heather Spencer-Fiegelsen and Thun, {Michael J.} and Carmen Rodriguez and Demetrius Albanes and Jarmo Virtamo and Stephanie Weinstein and Schumacher, {Fredrick R.} and Edward Giovannucci and Willett, {Walter C.} and Geraldine Cancel-Tassin and Olivier Cussenot and Antoine Valeri and Andriole, {Gerald L.} and Gelmann, {Edward P.} and Margaret Tucker and Gerhard, {Daniela S.} and Fraumeni, {Joseph F.} and Robert Hoover and Hunter, {David J.} and Chanock, {Stephen J.} and Gilles Thomas",
year = "2007",
month = may,
doi = "10.1038/ng2022",
language = "English",
volume = "39",
pages = "645--649",
journal = "Nature Genetics",
issn = "1546-1718",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.

AU - Yeager, Meredith

AU - Orr, Nick

AU - Hayes, Richard B.

AU - Jacobs, Kevin B.

AU - Kraft, Peter

AU - Wacholder, Sholom

AU - Minichiello, Mark J.

AU - Fearnhead, Paul

AU - Kai, Yu

AU - Chatterjee, Nilanjan

AU - Zhaoming, Wang

AU - Welch, Robert

AU - Staats, Brian J.

AU - Calle, Eugenia E.

AU - Spencer-Fiegelsen, Heather

AU - Thun, Michael J.

AU - Rodriguez, Carmen

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Weinstein, Stephanie

AU - Schumacher, Fredrick R.

AU - Giovannucci, Edward

AU - Willett, Walter C.

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Valeri, Antoine

AU - Andriole, Gerald L.

AU - Gelmann, Edward P.

AU - Tucker, Margaret

AU - Gerhard, Daniela S.

AU - Fraumeni, Joseph F.

AU - Hoover, Robert

AU - Hunter, David J.

AU - Chanock, Stephen J.

AU - Thomas, Gilles

PY - 2007/5

Y1 - 2007/5

N2 - Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 times 10-13; heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13–1.41; homozygote OR: 1.58, 95% c.i.: 1.40–1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 P = 1.41 times 10-11; rs6983267 P = 6.62 times 10-10). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%).

AB - Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 times 10-13; heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13–1.41; homozygote OR: 1.58, 95% c.i.: 1.40–1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 P = 1.41 times 10-11; rs6983267 P = 6.62 times 10-10). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%).

U2 - 10.1038/ng2022

DO - 10.1038/ng2022

M3 - Journal article

VL - 39

SP - 645

EP - 649

JO - Nature Genetics

JF - Nature Genetics

SN - 1546-1718

IS - 5

ER -