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Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay

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Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay. / Hong, Sung-Ha; Szili, Endre J.; Fenech, Michael et al.
In: Scientific Reports, 20.06.2017.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hong, S-H, Szili, EJ, Fenech, M, Gaur, N & Short, RD 2017, 'Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay', Scientific Reports. https://doi.org/10.1038/s41598-017-03754-1

APA

Hong, S-H., Szili, E. J., Fenech, M., Gaur, N., & Short, R. D. (2017). Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay. Scientific Reports, Article 3854. https://doi.org/10.1038/s41598-017-03754-1

Vancouver

Hong S-H, Szili EJ, Fenech M, Gaur N, Short RD. Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay. Scientific Reports. 2017 Jun 20;3854. doi: 10.1038/s41598-017-03754-1

Author

Hong, Sung-Ha ; Szili, Endre J. ; Fenech, Michael et al. / Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay. In: Scientific Reports. 2017.

Bibtex

@article{cf8dbc8abb2c49ea940e1296a5b8845b,
title = "Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay",
abstract = "Despite growing interest in the application of atmospheric plasma jets as medical treatment strategies, there has been comparatively little research on the potential genotoxic and cytotoxic effects of plasma jet treatment. In this study, we have employed the cytokinesis block micronucleus cytome (CBMN-Cyt) assay with WIL2-NS B lymphoblastoid cells to test the potential genotoxicity, as well as the cytotoxicity, of toxic species generated in cell culture media by an argon (Ar) plasma jet. Elevated levels of cell death (necrosis) and occurrence of chromosomal damage (micronuclei MN, nculeoplasmic bridge NPBs and nuclear bus, Nbuds) were observed when cells were exposed to plasma jet-treated media. These results provide a first insight into how we might measure the genotoxic and cytotoxic effect of plasma jet treatments (both indirect and direct) in dividing human cells.",
author = "Sung-Ha Hong and Szili, {Endre J.} and Michael Fenech and Nishtha Gaur and Short, {Robert D}",
year = "2017",
month = jun,
day = "20",
doi = "10.1038/s41598-017-03754-1",
language = "English",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Genotoxicity and cytotoxicity of the plasma jet-treated medium on lymphoblastoid WIL2-NS cell line using the cytokinesis block micronucleus cytome assay

AU - Hong, Sung-Ha

AU - Szili, Endre J.

AU - Fenech, Michael

AU - Gaur, Nishtha

AU - Short, Robert D

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Despite growing interest in the application of atmospheric plasma jets as medical treatment strategies, there has been comparatively little research on the potential genotoxic and cytotoxic effects of plasma jet treatment. In this study, we have employed the cytokinesis block micronucleus cytome (CBMN-Cyt) assay with WIL2-NS B lymphoblastoid cells to test the potential genotoxicity, as well as the cytotoxicity, of toxic species generated in cell culture media by an argon (Ar) plasma jet. Elevated levels of cell death (necrosis) and occurrence of chromosomal damage (micronuclei MN, nculeoplasmic bridge NPBs and nuclear bus, Nbuds) were observed when cells were exposed to plasma jet-treated media. These results provide a first insight into how we might measure the genotoxic and cytotoxic effect of plasma jet treatments (both indirect and direct) in dividing human cells.

AB - Despite growing interest in the application of atmospheric plasma jets as medical treatment strategies, there has been comparatively little research on the potential genotoxic and cytotoxic effects of plasma jet treatment. In this study, we have employed the cytokinesis block micronucleus cytome (CBMN-Cyt) assay with WIL2-NS B lymphoblastoid cells to test the potential genotoxicity, as well as the cytotoxicity, of toxic species generated in cell culture media by an argon (Ar) plasma jet. Elevated levels of cell death (necrosis) and occurrence of chromosomal damage (micronuclei MN, nculeoplasmic bridge NPBs and nuclear bus, Nbuds) were observed when cells were exposed to plasma jet-treated media. These results provide a first insight into how we might measure the genotoxic and cytotoxic effect of plasma jet treatments (both indirect and direct) in dividing human cells.

U2 - 10.1038/s41598-017-03754-1

DO - 10.1038/s41598-017-03754-1

M3 - Journal article

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 3854

ER -