Home > Research > Publications & Outputs > Germline Genetic Modification and Identity

Links

Text available via DOI:

View graph of relations

Germline Genetic Modification and Identity: the Mitochondrial and Nuclear Genomes

Research output: Contribution to journalJournal article

Published

Standard

Germline Genetic Modification and Identity : the Mitochondrial and Nuclear Genomes. / Scott, Rosamund; Wilkinson, Stephen Derek.

In: Oxford Journal of Legal Studies, Vol. 37, No. 4, 01.12.2017, p. 886-915.

Research output: Contribution to journalJournal article

Harvard

APA

Vancouver

Author

Scott, Rosamund ; Wilkinson, Stephen Derek. / Germline Genetic Modification and Identity : the Mitochondrial and Nuclear Genomes. In: Oxford Journal of Legal Studies. 2017 ; Vol. 37, No. 4. pp. 886-915.

Bibtex

@article{09c2dcade7d54d608a8f17ea4f50fe4e,
title = "Germline Genetic Modification and Identity: the Mitochondrial and Nuclear Genomes",
abstract = "In a legal {\textquoteleft}first{\textquoteright}, the UK removed a prohibition against modifying embryos in human reproduction, to enable mitochondrial replacement techniques (MRTs), a move the Government distanced from {\textquoteleft}germline genetic modification{\textquoteright}, which it aligned with modifying the nuclear genome. This paper (1) analyzes the uses and meanings of this term in UK/US legal and policy debates; and (2) evaluates related ethical concerns about identity. It shows that, with respect to identity, MRTs and nuclear genome editing techniques such as CRISPR/Cas-9 (now a policy topic), are not as different as has been supposed. While it does not follow that the two should be treated exactly alike, one of the central reasons offered for treating MRTs more permissively than nuclear genetic modification, and for not regarding MRTs as {\textquoteleft}germline genetic modification{\textquoteright}, is thereby in doubt. Identity cannot, by itself, do the work thus far assigned to it, explicitly or otherwise, in law and policy.",
keywords = "mitochondrial replacement, identity, Germline, Genome, Human, Genetic modification, CRISPR/Cas-9",
author = "Rosamund Scott and Wilkinson, {Stephen Derek}",
year = "2017",
month = dec
day = "1",
doi = "10.1093/ojls/gqx012",
language = "English",
volume = "37",
pages = "886--915",
journal = "Oxford Journal of Legal Studies",
issn = "0143-6503",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Germline Genetic Modification and Identity

T2 - the Mitochondrial and Nuclear Genomes

AU - Scott, Rosamund

AU - Wilkinson, Stephen Derek

PY - 2017/12/1

Y1 - 2017/12/1

N2 - In a legal ‘first’, the UK removed a prohibition against modifying embryos in human reproduction, to enable mitochondrial replacement techniques (MRTs), a move the Government distanced from ‘germline genetic modification’, which it aligned with modifying the nuclear genome. This paper (1) analyzes the uses and meanings of this term in UK/US legal and policy debates; and (2) evaluates related ethical concerns about identity. It shows that, with respect to identity, MRTs and nuclear genome editing techniques such as CRISPR/Cas-9 (now a policy topic), are not as different as has been supposed. While it does not follow that the two should be treated exactly alike, one of the central reasons offered for treating MRTs more permissively than nuclear genetic modification, and for not regarding MRTs as ‘germline genetic modification’, is thereby in doubt. Identity cannot, by itself, do the work thus far assigned to it, explicitly or otherwise, in law and policy.

AB - In a legal ‘first’, the UK removed a prohibition against modifying embryos in human reproduction, to enable mitochondrial replacement techniques (MRTs), a move the Government distanced from ‘germline genetic modification’, which it aligned with modifying the nuclear genome. This paper (1) analyzes the uses and meanings of this term in UK/US legal and policy debates; and (2) evaluates related ethical concerns about identity. It shows that, with respect to identity, MRTs and nuclear genome editing techniques such as CRISPR/Cas-9 (now a policy topic), are not as different as has been supposed. While it does not follow that the two should be treated exactly alike, one of the central reasons offered for treating MRTs more permissively than nuclear genetic modification, and for not regarding MRTs as ‘germline genetic modification’, is thereby in doubt. Identity cannot, by itself, do the work thus far assigned to it, explicitly or otherwise, in law and policy.

KW - mitochondrial replacement

KW - identity

KW - Germline

KW - Genome, Human

KW - Genetic modification

KW - CRISPR/Cas-9

U2 - 10.1093/ojls/gqx012

DO - 10.1093/ojls/gqx012

M3 - Journal article

VL - 37

SP - 886

EP - 915

JO - Oxford Journal of Legal Studies

JF - Oxford Journal of Legal Studies

SN - 0143-6503

IS - 4

ER -