TY - JOUR

T1 - Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents.

AU - Smith, Michael A.

AU - Riby, Leigh M.

AU - Sünram-Lea, Sandra I.

AU - van Eekelen, J. A. M.

AU - Foster, Jonathan K.

N1 - The original publication is available at www.springerlink.com

PY - 2009/7

Y1 - 2009/7

N2 - Introduction Behavioural evidence supports the notion that oral glucose ingestion enhances recognition memory judgements based on recollection, but not familiarity. The present study sought to clarify and extend upon these behavioural findings by investigating the influence of glucose administration on event-related potential (ERP) components that are thought to be differentially mediated by recollection and familiarity processes in healthy adolescents. Methods In a within-subjects design, participants performed a recognition memory task, during which time electroencephalogram (EEG) was recorded, subsequent to ingestion of either (a) glucose or (b) placebo in a counterbalanced order. Results Response times during the recognition memory task were observed to be faster for the glucose condition, relative to a placebo control. Further, glucose ingestion was associated with an enhanced left parietal old/new ERP effect (a marker of recollection) and an enhanced mid-frontal old/new ERP effect (known to be mediated by familiarity). Discussion These findings (a) support the results of previous research that the ‘glucose memory facilitation effect’ can be extended to healthy adolescents, but (b) suggest that glucose enhances both the recollection and familiarity components of recognition memory. The observed ERP profile has important implications for the proposal that glucose specifically targets the hippocampus in modulating cognitive performance.

AB - Introduction Behavioural evidence supports the notion that oral glucose ingestion enhances recognition memory judgements based on recollection, but not familiarity. The present study sought to clarify and extend upon these behavioural findings by investigating the influence of glucose administration on event-related potential (ERP) components that are thought to be differentially mediated by recollection and familiarity processes in healthy adolescents. Methods In a within-subjects design, participants performed a recognition memory task, during which time electroencephalogram (EEG) was recorded, subsequent to ingestion of either (a) glucose or (b) placebo in a counterbalanced order. Results Response times during the recognition memory task were observed to be faster for the glucose condition, relative to a placebo control. Further, glucose ingestion was associated with an enhanced left parietal old/new ERP effect (a marker of recollection) and an enhanced mid-frontal old/new ERP effect (known to be mediated by familiarity). Discussion These findings (a) support the results of previous research that the ‘glucose memory facilitation effect’ can be extended to healthy adolescents, but (b) suggest that glucose enhances both the recollection and familiarity components of recognition memory. The observed ERP profile has important implications for the proposal that glucose specifically targets the hippocampus in modulating cognitive performance.

KW - Recognition memory - Glucose - Event-related potentials - Adolescents

U2 - 10.1007/s00213-009-1509-4

DO - 10.1007/s00213-009-1509-4

M3 - Journal article

VL - 205

SP - 11

EP - 20

JO - Psychopharmacology

JF - Psychopharmacology

SN - 1432-2072

IS - 1

ER -