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Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

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Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. / Yeung, Ching Yan Chloé; Gossan, Nicole; Lu, Yinhui; Hughes, Alun; Hensman, James J.; Bayer, Monika L.; Kjær, Michael; Kadler, Karl E.; Meng, Qing Jun.

In: Scientific Reports, Vol. 4, 5183, 05.06.2014.

Research output: Contribution to journalJournal article

Harvard

Yeung, CYC, Gossan, N, Lu, Y, Hughes, A, Hensman, JJ, Bayer, ML, Kjær, M, Kadler, KE & Meng, QJ 2014, 'Gremlin-2 is a BMP antagonist that is regulated by the circadian clock', Scientific Reports, vol. 4, 5183. https://doi.org/10.1038/srep05183

APA

Yeung, C. Y. C., Gossan, N., Lu, Y., Hughes, A., Hensman, J. J., Bayer, M. L., Kjær, M., Kadler, K. E., & Meng, Q. J. (2014). Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. Scientific Reports, 4, [5183]. https://doi.org/10.1038/srep05183

Vancouver

Yeung CYC, Gossan N, Lu Y, Hughes A, Hensman JJ, Bayer ML et al. Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. Scientific Reports. 2014 Jun 5;4. 5183. https://doi.org/10.1038/srep05183

Author

Yeung, Ching Yan Chloé ; Gossan, Nicole ; Lu, Yinhui ; Hughes, Alun ; Hensman, James J. ; Bayer, Monika L. ; Kjær, Michael ; Kadler, Karl E. ; Meng, Qing Jun. / Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. In: Scientific Reports. 2014 ; Vol. 4.

Bibtex

@article{0dae66d24ef2488cb6c0ff324a21be63,
title = "Gremlin-2 is a BMP antagonist that is regulated by the circadian clock",
abstract = "Tendons are prominent members of the family of fibrous connective tissues (FCTs), which collectively are the most abundant tissues in vertebrates and have crucial roles in transmitting mechanical force and linking organs. Tendon diseases are among the most common arthropathy disorders; thus knowledge of tendon gene regulation is essential for a complete understanding of FCT biology. Here we show autonomous circadian rhythms in mouse tendon and primary human tenocytes, controlled by an intrinsic molecular circadian clock. Time-series microarrays identified the first circadian transcriptome of murine tendon, revealing that 4.6% of the transcripts (745 genes) are expressed in a circadian manner. One of these genes was Grem2, which oscillated in antiphase to BMP signaling. Moreover, recombinant human Gremlin-2 blocked BMP2-induced phosphorylation of Smad1/5 and osteogenic differentiation of human tenocytes in vitro. We observed dampened Grem2 expression, deregulated BMP signaling, and spontaneously calcifying tendons in young CLOCK{\^I} {"}19 arrhythmic mice and aged wild-type mice. Thus, disruption of circadian control, through mutations or aging, of Grem2/BMP signaling becomes a new focus for the study of calcific tendinopathy, which affects 1-in-5 people over the age of 50 years.",
author = "Yeung, {Ching Yan Chlo{\'e}} and Nicole Gossan and Yinhui Lu and Alun Hughes and Hensman, {James J.} and Bayer, {Monika L.} and Michael Kj{\ae}r and Kadler, {Karl E.} and Meng, {Qing Jun}",
year = "2014",
month = jun,
day = "5",
doi = "10.1038/srep05183",
language = "English",
volume = "4",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Gremlin-2 is a BMP antagonist that is regulated by the circadian clock

AU - Yeung, Ching Yan Chloé

AU - Gossan, Nicole

AU - Lu, Yinhui

AU - Hughes, Alun

AU - Hensman, James J.

AU - Bayer, Monika L.

AU - Kjær, Michael

AU - Kadler, Karl E.

AU - Meng, Qing Jun

PY - 2014/6/5

Y1 - 2014/6/5

N2 - Tendons are prominent members of the family of fibrous connective tissues (FCTs), which collectively are the most abundant tissues in vertebrates and have crucial roles in transmitting mechanical force and linking organs. Tendon diseases are among the most common arthropathy disorders; thus knowledge of tendon gene regulation is essential for a complete understanding of FCT biology. Here we show autonomous circadian rhythms in mouse tendon and primary human tenocytes, controlled by an intrinsic molecular circadian clock. Time-series microarrays identified the first circadian transcriptome of murine tendon, revealing that 4.6% of the transcripts (745 genes) are expressed in a circadian manner. One of these genes was Grem2, which oscillated in antiphase to BMP signaling. Moreover, recombinant human Gremlin-2 blocked BMP2-induced phosphorylation of Smad1/5 and osteogenic differentiation of human tenocytes in vitro. We observed dampened Grem2 expression, deregulated BMP signaling, and spontaneously calcifying tendons in young CLOCKÎ "19 arrhythmic mice and aged wild-type mice. Thus, disruption of circadian control, through mutations or aging, of Grem2/BMP signaling becomes a new focus for the study of calcific tendinopathy, which affects 1-in-5 people over the age of 50 years.

AB - Tendons are prominent members of the family of fibrous connective tissues (FCTs), which collectively are the most abundant tissues in vertebrates and have crucial roles in transmitting mechanical force and linking organs. Tendon diseases are among the most common arthropathy disorders; thus knowledge of tendon gene regulation is essential for a complete understanding of FCT biology. Here we show autonomous circadian rhythms in mouse tendon and primary human tenocytes, controlled by an intrinsic molecular circadian clock. Time-series microarrays identified the first circadian transcriptome of murine tendon, revealing that 4.6% of the transcripts (745 genes) are expressed in a circadian manner. One of these genes was Grem2, which oscillated in antiphase to BMP signaling. Moreover, recombinant human Gremlin-2 blocked BMP2-induced phosphorylation of Smad1/5 and osteogenic differentiation of human tenocytes in vitro. We observed dampened Grem2 expression, deregulated BMP signaling, and spontaneously calcifying tendons in young CLOCKÎ "19 arrhythmic mice and aged wild-type mice. Thus, disruption of circadian control, through mutations or aging, of Grem2/BMP signaling becomes a new focus for the study of calcific tendinopathy, which affects 1-in-5 people over the age of 50 years.

U2 - 10.1038/srep05183

DO - 10.1038/srep05183

M3 - Journal article

AN - SCOPUS:84902106530

VL - 4

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 5183

ER -