Research output: Contribution to journal › Journal article
|<mark>Journal publication date</mark>||2009|
|<mark>Journal</mark>||Organic and Biomolecular Chemistry|
|Number of pages||14|
A new and efficient desymmetrisation of succinic and glutaric cyclic meso-anhydrides is described, providing excellent yields and diastereoselectivities in most cases. Derivatisation of the desymmetrised products is demonstrated by their conversion into mono-protected 1,4-diols. General synthetic utility of the method is established by its application towards a key fragment in the total synthesis of the immunosuppressant antitumour natural product, rapamycin.