Research output: Contribution to Journal/Magazine › Journal article › peer-review
| <mark>Journal publication date</mark> | 2009 |
|---|---|
| <mark>Journal</mark> | Organic and Biomolecular Chemistry |
| Issue number | 4 |
| Volume | 7 |
| Number of pages | 14 |
| Pages (from-to) | 747-760 |
| Publication Status | Published |
| <mark>Original language</mark> | English |
A new and efficient desymmetrisation of succinic and glutaric cyclic meso-anhydrides is described, providing excellent yields and diastereoselectivities in most cases. Derivatisation of the desymmetrised products is demonstrated by their conversion into mono-protected 1,4-diols. General synthetic utility of the method is established by its application towards a key fragment in the total synthesis of the immunosuppressant antitumour natural product, rapamycin.