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    Rights statement: Copyright of ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00807

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Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

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Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. / Hardy, John George; Larraneta, Eneko; Donnelly, Ryan et al.
In: Molecular Pharmaceutics, Vol. 13, No. 3, 07.03.2016, p. 907-914.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Hardy, JG, Larraneta, E, Donnelly, R, McGoldrick, N, Migalska, K, McCrudden, M, Donnelly, L & McCoy, C 2016, 'Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery', Molecular Pharmaceutics, vol. 13, no. 3, pp. 907-914. https://doi.org/10.1021/acs.molpharmaceut.5b00807

APA

Hardy, J. G., Larraneta, E., Donnelly, R., McGoldrick, N., Migalska, K., McCrudden, M., Donnelly, L., & McCoy, C. (2016). Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. Molecular Pharmaceutics, 13(3), 907-914. https://doi.org/10.1021/acs.molpharmaceut.5b00807

Vancouver

Hardy JG, Larraneta E, Donnelly R, McGoldrick N, Migalska K, McCrudden M et al. Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. Molecular Pharmaceutics. 2016 Mar 7;13(3):907-914. Epub 2016 Jan 21. doi: 10.1021/acs.molpharmaceut.5b00807

Author

Hardy, John George ; Larraneta, Eneko ; Donnelly, Ryan et al. / Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. In: Molecular Pharmaceutics. 2016 ; Vol. 13, No. 3. pp. 907-914.

Bibtex

@article{7d363e3fc2404a759df4c6f8b8fcb62b,
title = "Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery",
abstract = "We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in “on-demand” delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.",
keywords = "hydrogel, biomaterials, drug delivery, pharmacy, light",
author = "Hardy, {John George} and Eneko Larraneta and Ryan Donnelly and Niamh McGoldrick and Katarzyna Migalska and Maeliosa McCrudden and Louise Donnelly and Colin McCoy",
note = "Copyright of ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright {\textcopyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00807",
year = "2016",
month = mar,
day = "7",
doi = "10.1021/acs.molpharmaceut.5b00807",
language = "English",
volume = "13",
pages = "907--914",
journal = "Molecular Pharmaceutics",
issn = "1543-8392",
publisher = "ACS",
number = "3",

}

RIS

TY - JOUR

T1 - Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

AU - Hardy, John George

AU - Larraneta, Eneko

AU - Donnelly, Ryan

AU - McGoldrick, Niamh

AU - Migalska, Katarzyna

AU - McCrudden, Maeliosa

AU - Donnelly, Louise

AU - McCoy, Colin

N1 - Copyright of ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00807

PY - 2016/3/7

Y1 - 2016/3/7

N2 - We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in “on-demand” delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

AB - We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in “on-demand” delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

KW - hydrogel

KW - biomaterials

KW - drug delivery

KW - pharmacy

KW - light

U2 - 10.1021/acs.molpharmaceut.5b00807

DO - 10.1021/acs.molpharmaceut.5b00807

M3 - Journal article

VL - 13

SP - 907

EP - 914

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8392

IS - 3

ER -