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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. / Tsoi, Lam C.; Spain, Sarah L.; Knight, Jo; Ellinghaus, Eva; Stuart, Philip E.; Capon, Francesca; Ding, Jun; Li, Yanming; Tejasvi, Trilokraj; Gudjonsson, Johann E.; Kang, Hyun M.; Allen, Michael H.; McManus, Ross; Novelli, Giuseppe; Samuelsson, Lena; Schalkwijk, Joost; Ståhle, Mona; Burden, A. David; Smith, Catherine H.; Cork, Michael J.; Estivill, Xavier; Bowcock, Anne M.; Krueger, Gerald G.; Weger, Wolfgang; Worthington, Jane; Tazi-Ahnini, Rachid; Nestle, Frank O.; Hayday, Adrian; Hoffmann, Per; Winkelmann, Juliane; Wijmenga, Cisca; Langford, Cordelia; Edkins, Sarah; Andrews, Robert; Blackburn, Hannah; Strange, Amy; Band, Gavin; Pearson, Richard D.; Vukcevic, Damjan; Spencer, Chris C. A.; Deloukas, Panos; Mrowietz, Ulrich; Schreiber, Stefan; Weidinger, Stephan; Koks, Sulev; Kingo, Külli; Esko, Tonu; Metspalu, Andres; Lim, Henry W.; Voorhees, John J.; Collaborative Association Study of Psoriasis (CASP).

In: Nature Genetics, Vol. 44, No. 12, 12.2012, p. 1341-1348.

Research output: Contribution to journalLetterpeer-review

Harvard

Tsoi, LC, Spain, SL, Knight, J, Ellinghaus, E, Stuart, PE, Capon, F, Ding, J, Li, Y, Tejasvi, T, Gudjonsson, JE, Kang, HM, Allen, MH, McManus, R, Novelli, G, Samuelsson, L, Schalkwijk, J, Ståhle, M, Burden, AD, Smith, CH, Cork, MJ, Estivill, X, Bowcock, AM, Krueger, GG, Weger, W, Worthington, J, Tazi-Ahnini, R, Nestle, FO, Hayday, A, Hoffmann, P, Winkelmann, J, Wijmenga, C, Langford, C, Edkins, S, Andrews, R, Blackburn, H, Strange, A, Band, G, Pearson, RD, Vukcevic, D, Spencer, CCA, Deloukas, P, Mrowietz, U, Schreiber, S, Weidinger, S, Koks, S, Kingo, K, Esko, T, Metspalu, A, Lim, HW, Voorhees, JJ & Collaborative Association Study of Psoriasis (CASP) 2012, 'Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity', Nature Genetics, vol. 44, no. 12, pp. 1341-1348. https://doi.org/10.1038/ng.2467

APA

Tsoi, L. C., Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, J. E., Kang, H. M., Allen, M. H., McManus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Ståhle, M., Burden, A. D., Smith, C. H., ... Collaborative Association Study of Psoriasis (CASP) (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics, 44(12), 1341-1348. https://doi.org/10.1038/ng.2467

Vancouver

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics. 2012 Dec;44(12):1341-1348. https://doi.org/10.1038/ng.2467

Author

Tsoi, Lam C. ; Spain, Sarah L. ; Knight, Jo ; Ellinghaus, Eva ; Stuart, Philip E. ; Capon, Francesca ; Ding, Jun ; Li, Yanming ; Tejasvi, Trilokraj ; Gudjonsson, Johann E. ; Kang, Hyun M. ; Allen, Michael H. ; McManus, Ross ; Novelli, Giuseppe ; Samuelsson, Lena ; Schalkwijk, Joost ; Ståhle, Mona ; Burden, A. David ; Smith, Catherine H. ; Cork, Michael J. ; Estivill, Xavier ; Bowcock, Anne M. ; Krueger, Gerald G. ; Weger, Wolfgang ; Worthington, Jane ; Tazi-Ahnini, Rachid ; Nestle, Frank O. ; Hayday, Adrian ; Hoffmann, Per ; Winkelmann, Juliane ; Wijmenga, Cisca ; Langford, Cordelia ; Edkins, Sarah ; Andrews, Robert ; Blackburn, Hannah ; Strange, Amy ; Band, Gavin ; Pearson, Richard D. ; Vukcevic, Damjan ; Spencer, Chris C. A. ; Deloukas, Panos ; Mrowietz, Ulrich ; Schreiber, Stefan ; Weidinger, Stephan ; Koks, Sulev ; Kingo, Külli ; Esko, Tonu ; Metspalu, Andres ; Lim, Henry W. ; Voorhees, John J. ; Collaborative Association Study of Psoriasis (CASP). / Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. In: Nature Genetics. 2012 ; Vol. 44, No. 12. pp. 1341-1348.

Bibtex

@article{5d55b742d1354782893a457ca9f48bf4,
title = "Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity",
abstract = "To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.",
keywords = "CARD Signaling Adaptor Proteins, Core Binding Factor Alpha 3 Subunit, DEAD-box RNA Helicases, European Continental Ancestry Group, GTPase-Activating Proteins, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanylate Cyclase, Humans, Immunity, Innate, Membrane Proteins, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Psoriasis, STAT3 Transcription Factor, Skin, T-Lymphocytes",
author = "Tsoi, {Lam C.} and Spain, {Sarah L.} and Jo Knight and Eva Ellinghaus and Stuart, {Philip E.} and Francesca Capon and Jun Ding and Yanming Li and Trilokraj Tejasvi and Gudjonsson, {Johann E.} and Kang, {Hyun M.} and Allen, {Michael H.} and Ross McManus and Giuseppe Novelli and Lena Samuelsson and Joost Schalkwijk and Mona St{\aa}hle and Burden, {A. David} and Smith, {Catherine H.} and Cork, {Michael J.} and Xavier Estivill and Bowcock, {Anne M.} and Krueger, {Gerald G.} and Wolfgang Weger and Jane Worthington and Rachid Tazi-Ahnini and Nestle, {Frank O.} and Adrian Hayday and Per Hoffmann and Juliane Winkelmann and Cisca Wijmenga and Cordelia Langford and Sarah Edkins and Robert Andrews and Hannah Blackburn and Amy Strange and Gavin Band and Pearson, {Richard D.} and Damjan Vukcevic and Spencer, {Chris C. A.} and Panos Deloukas and Ulrich Mrowietz and Stefan Schreiber and Stephan Weidinger and Sulev Koks and K{\"u}lli Kingo and Tonu Esko and Andres Metspalu and Lim, {Henry W.} and Voorhees, {John J.} and {Collaborative Association Study of Psoriasis (CASP)}",
year = "2012",
month = dec,
doi = "10.1038/ng.2467",
language = "English",
volume = "44",
pages = "1341--1348",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

AU - Tsoi, Lam C.

AU - Spain, Sarah L.

AU - Knight, Jo

AU - Ellinghaus, Eva

AU - Stuart, Philip E.

AU - Capon, Francesca

AU - Ding, Jun

AU - Li, Yanming

AU - Tejasvi, Trilokraj

AU - Gudjonsson, Johann E.

AU - Kang, Hyun M.

AU - Allen, Michael H.

AU - McManus, Ross

AU - Novelli, Giuseppe

AU - Samuelsson, Lena

AU - Schalkwijk, Joost

AU - Ståhle, Mona

AU - Burden, A. David

AU - Smith, Catherine H.

AU - Cork, Michael J.

AU - Estivill, Xavier

AU - Bowcock, Anne M.

AU - Krueger, Gerald G.

AU - Weger, Wolfgang

AU - Worthington, Jane

AU - Tazi-Ahnini, Rachid

AU - Nestle, Frank O.

AU - Hayday, Adrian

AU - Hoffmann, Per

AU - Winkelmann, Juliane

AU - Wijmenga, Cisca

AU - Langford, Cordelia

AU - Edkins, Sarah

AU - Andrews, Robert

AU - Blackburn, Hannah

AU - Strange, Amy

AU - Band, Gavin

AU - Pearson, Richard D.

AU - Vukcevic, Damjan

AU - Spencer, Chris C. A.

AU - Deloukas, Panos

AU - Mrowietz, Ulrich

AU - Schreiber, Stefan

AU - Weidinger, Stephan

AU - Koks, Sulev

AU - Kingo, Külli

AU - Esko, Tonu

AU - Metspalu, Andres

AU - Lim, Henry W.

AU - Voorhees, John J.

AU - Collaborative Association Study of Psoriasis (CASP)

PY - 2012/12

Y1 - 2012/12

N2 - To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

AB - To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

KW - CARD Signaling Adaptor Proteins

KW - Core Binding Factor Alpha 3 Subunit

KW - DEAD-box RNA Helicases

KW - European Continental Ancestry Group

KW - GTPase-Activating Proteins

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Guanylate Cyclase

KW - Humans

KW - Immunity, Innate

KW - Membrane Proteins

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - Psoriasis

KW - STAT3 Transcription Factor

KW - Skin

KW - T-Lymphocytes

U2 - 10.1038/ng.2467

DO - 10.1038/ng.2467

M3 - Letter

C2 - 23143594

VL - 44

SP - 1341

EP - 1348

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -