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Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness

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Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. / Urbaniak, Michael D.; Tabudravu, Jioji N.; Msaki, Aichi et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 22, 15.11.2006, p. 5744-5747.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Urbaniak, MD, Tabudravu, JN, Msaki, A, Matera, KM, Brenk, R, Jaspars, M & Ferguson, MAJ 2006, 'Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness', Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 22, pp. 5744-5747. https://doi.org/10.1016/j.bmcl.2006.08.091

APA

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M., & Ferguson, M. A. J. (2006). Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorganic and Medicinal Chemistry Letters, 16(22), 5744-5747. https://doi.org/10.1016/j.bmcl.2006.08.091

Vancouver

Urbaniak MD, Tabudravu JN, Msaki A, Matera KM, Brenk R, Jaspars M et al. Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorganic and Medicinal Chemistry Letters. 2006 Nov 15;16(22):5744-5747. doi: 10.1016/j.bmcl.2006.08.091

Author

Urbaniak, Michael D. ; Tabudravu, Jioji N. ; Msaki, Aichi et al. / Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 22. pp. 5744-5747.

Bibtex

@article{b2c8010325e44e5fae174f9a8eef5b0a,
title = "Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness",
abstract = "Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.",
keywords = "Animals, Enzyme Inhibitors, Humans, Models, Chemical, Trypanocidal Agents, Trypanosoma brucei brucei, Trypanosomiasis, African, UDPglucose 4-Epimerase",
author = "Urbaniak, {Michael D.} and Tabudravu, {Jioji N.} and Aichi Msaki and Matera, {Kathy Mansfield} and Ruth Brenk and Marcel Jaspars and Ferguson, {Michael A. J.}",
year = "2006",
month = nov,
day = "15",
doi = "10.1016/j.bmcl.2006.08.091",
language = "English",
volume = "16",
pages = "5744--5747",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "22",

}

RIS

TY - JOUR

T1 - Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness

AU - Urbaniak, Michael D.

AU - Tabudravu, Jioji N.

AU - Msaki, Aichi

AU - Matera, Kathy Mansfield

AU - Brenk, Ruth

AU - Jaspars, Marcel

AU - Ferguson, Michael A. J.

PY - 2006/11/15

Y1 - 2006/11/15

N2 - Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.

AB - Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.

KW - Animals

KW - Enzyme Inhibitors

KW - Humans

KW - Models, Chemical

KW - Trypanocidal Agents

KW - Trypanosoma brucei brucei

KW - Trypanosomiasis, African

KW - UDPglucose 4-Epimerase

U2 - 10.1016/j.bmcl.2006.08.091

DO - 10.1016/j.bmcl.2006.08.091

M3 - Journal article

C2 - 16962325

VL - 16

SP - 5744

EP - 5747

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -