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IFI16 is an innate immune sensor for intracellular DNA

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IFI16 is an innate immune sensor for intracellular DNA. / Unterholzner, Leonie; Keating, Sinead E.; Baran, Marcin; Horan, Kristy A.; Jensen, Søren B.; Sharma, Shruti; Sirois, Cherilyn M.; Jin, Tengchuan; Latz, Eicke; Xiao, T. Sam; Fitzgerald, Katherine A.; Paludan, Søren R.; Bowie, Andrew G.

In: Nature Immunology, Vol. 11, No. 11, 11.2010, p. 997-1004.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Unterholzner, L, Keating, SE, Baran, M, Horan, KA, Jensen, SB, Sharma, S, Sirois, CM, Jin, T, Latz, E, Xiao, TS, Fitzgerald, KA, Paludan, SR & Bowie, AG 2010, 'IFI16 is an innate immune sensor for intracellular DNA', Nature Immunology, vol. 11, no. 11, pp. 997-1004. https://doi.org/10.1038/ni.1932

APA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., Fitzgerald, K. A., Paludan, S. R., & Bowie, A. G. (2010). IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology, 11(11), 997-1004. https://doi.org/10.1038/ni.1932

Vancouver

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S et al. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology. 2010 Nov;11(11):997-1004. https://doi.org/10.1038/ni.1932

Author

Unterholzner, Leonie ; Keating, Sinead E. ; Baran, Marcin ; Horan, Kristy A. ; Jensen, Søren B. ; Sharma, Shruti ; Sirois, Cherilyn M. ; Jin, Tengchuan ; Latz, Eicke ; Xiao, T. Sam ; Fitzgerald, Katherine A. ; Paludan, Søren R. ; Bowie, Andrew G. / IFI16 is an innate immune sensor for intracellular DNA. In: Nature Immunology. 2010 ; Vol. 11, No. 11. pp. 997-1004.

Bibtex

@article{15e208c550c443e88c1605b62a2cef68,
title = "IFI16 is an innate immune sensor for intracellular DNA",
abstract = "The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-κB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs).",
keywords = "Animals, Cell Line, DNA, Viral, DNA-Binding Proteins, Herpesvirus 1, Human, Humans, Immunity, Innate, Interferon-beta, Intracellular Space, Membrane Proteins, Mice, Monocytes, Nuclear Proteins, Phosphoproteins, Signal Transduction",
author = "Leonie Unterholzner and Keating, {Sinead E.} and Marcin Baran and Horan, {Kristy A.} and Jensen, {S{\o}ren B.} and Shruti Sharma and Sirois, {Cherilyn M.} and Tengchuan Jin and Eicke Latz and Xiao, {T. Sam} and Fitzgerald, {Katherine A.} and Paludan, {S{\o}ren R.} and Bowie, {Andrew G.}",
year = "2010",
month = nov,
doi = "10.1038/ni.1932",
language = "English",
volume = "11",
pages = "997--1004",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - IFI16 is an innate immune sensor for intracellular DNA

AU - Unterholzner, Leonie

AU - Keating, Sinead E.

AU - Baran, Marcin

AU - Horan, Kristy A.

AU - Jensen, Søren B.

AU - Sharma, Shruti

AU - Sirois, Cherilyn M.

AU - Jin, Tengchuan

AU - Latz, Eicke

AU - Xiao, T. Sam

AU - Fitzgerald, Katherine A.

AU - Paludan, Søren R.

AU - Bowie, Andrew G.

PY - 2010/11

Y1 - 2010/11

N2 - The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-κB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs).

AB - The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-κB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs).

KW - Animals

KW - Cell Line

KW - DNA, Viral

KW - DNA-Binding Proteins

KW - Herpesvirus 1, Human

KW - Humans

KW - Immunity, Innate

KW - Interferon-beta

KW - Intracellular Space

KW - Membrane Proteins

KW - Mice

KW - Monocytes

KW - Nuclear Proteins

KW - Phosphoproteins

KW - Signal Transduction

U2 - 10.1038/ni.1932

DO - 10.1038/ni.1932

M3 - Journal article

C2 - 20890285

VL - 11

SP - 997

EP - 1004

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 11

ER -