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    Rights statement: Copyright: © 2012 Ndibazza et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial

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Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial. / Ndibazza, Juliet; Mpairwe, Harriet; Webb, Emily L. et al.
In: PLoS ONE, Vol. 7, No. 12, 07.12.2012, p. e50325 EP -.

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Harvard

Ndibazza, J, Mpairwe, H, Webb, EL, Mawa, PA, Nampijja, M, Muhangi, L, Kihembo, M, Lule, SA, Rutebarika, D, Apule, B, Akello, F, Akurut, H, Oduru, G, Naniima, P, Kizito, D, Kizza, M, Kizindo, R, Tweyongere, R, Alcock, KJ, Muwanga, M & Elliott, AM 2012, 'Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial', PLoS ONE, vol. 7, no. 12, pp. e50325 EP -. https://doi.org/10.1371%2Fjournal.pone.0050325

APA

Ndibazza, J., Mpairwe, H., Webb, E. L., Mawa, P. A., Nampijja, M., Muhangi, L., Kihembo, M., Lule, S. A., Rutebarika, D., Apule, B., Akello, F., Akurut, H., Oduru, G., Naniima, P., Kizito, D., Kizza, M., Kizindo, R., Tweyongere, R., Alcock, K. J., ... Elliott, A. M. (2012). Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial. PLoS ONE, 7(12), e50325 EP -. https://doi.org/10.1371%2Fjournal.pone.0050325

Vancouver

Ndibazza J, Mpairwe H, Webb EL, Mawa PA, Nampijja M, Muhangi L et al. Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial. PLoS ONE. 2012 Dec 7;7(12):e50325 EP -. doi: 10.1371%2Fjournal.pone.0050325

Author

Ndibazza, Juliet ; Mpairwe, Harriet ; Webb, Emily L. et al. / Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood : A Randomised Controlled Trial. In: PLoS ONE. 2012 ; Vol. 7, No. 12. pp. e50325 EP -.

Bibtex

@article{6e8c05c008f04884b8e54b32293846dc,
title = "Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial",
abstract = "Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to immunisation and modulate disease incidence in early childhood with both beneficial and detrimental effects.A randomised, double-blind, placebo-controlled trial was conducted in Entebbe, Uganda [ISRCTN32849447]. In three independent randomisations, 2507 pregnant women were allocated to receive single-dose albendazole or placebo, and praziquantel or placebo; 2016 of their offspring were randomised to receive quarterly single-dose albendazole or placebo from age 15 months to 5 years. Primary outcomes were post-immunisation recall responses to BCG and tetanus antigens, and incidence of malaria, diarrhoea, and pneumonia; incidence of eczema was an important secondary outcome. Analysis was by intention-to-treat. Of 2345 live births, 1622 (69%) children remained in follow-up at age 5 years. 68% of mothers at enrolment, and 11% of five-year-olds, had helminth infections. Maternal hookworm and Schistosoma mansoni were effectively treated by albendazole and praziquantel, respectively; and childhood hookworm and Ascaris by quarterly albendazole. Incidence rates of malaria, diarrhoea, pneumonia, and eczema were 34, 65, 10 and 5 per 100 py, respectively. Albendazole during pregnancy caused an increased rate of eczema in the children (HR 1.58 (95% CI 1.15‚{\"A}{\`i}2.17), p‚{\"A}{\"a}=‚{\"A}{\"a}0.005). Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73‚{\"A}{\`i}0.98), p‚{\"A}{\"a}=‚{\"A}{\"a}0.03). There were no consistent effects of the interventions on any other outcome.Routine use of albendazole in pregnancy may not always be beneficial, even in tropical developing countries. By contrast, regular albendazole treatment in preschool children may have an additional benefit for malaria control where helminths and malaria are co-endemic. Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.Current Controlled Trials ISRCTN32849447",
author = "Juliet Ndibazza and Harriet Mpairwe and Webb, {Emily L.} and Mawa, {Patrice A.} and Margaret Nampijja and Lawrence Muhangi and Macklyn Kihembo and Lule, {Swaib A.} and Diana Rutebarika and Barbara Apule and Florence Akello and Hellen Akurut and Gloria Oduru and Peter Naniima and Dennison Kizito and Moses Kizza and Robert Kizindo and Robert Tweyongere and Alcock, {Katherine J.} and Moses Muwanga and Elliott, {Alison M.}",
note = "Copyright: {\textcopyright} 2012 Ndibazza et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2012",
month = dec,
day = "7",
doi = "10.1371%2Fjournal.pone.0050325",
language = "English",
volume = "7",
pages = "e50325 EP --",
journal = "PLoS ONE",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood

T2 - A Randomised Controlled Trial

AU - Ndibazza, Juliet

AU - Mpairwe, Harriet

AU - Webb, Emily L.

AU - Mawa, Patrice A.

AU - Nampijja, Margaret

AU - Muhangi, Lawrence

AU - Kihembo, Macklyn

AU - Lule, Swaib A.

AU - Rutebarika, Diana

AU - Apule, Barbara

AU - Akello, Florence

AU - Akurut, Hellen

AU - Oduru, Gloria

AU - Naniima, Peter

AU - Kizito, Dennison

AU - Kizza, Moses

AU - Kizindo, Robert

AU - Tweyongere, Robert

AU - Alcock, Katherine J.

AU - Muwanga, Moses

AU - Elliott, Alison M.

N1 - Copyright: © 2012 Ndibazza et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to immunisation and modulate disease incidence in early childhood with both beneficial and detrimental effects.A randomised, double-blind, placebo-controlled trial was conducted in Entebbe, Uganda [ISRCTN32849447]. In three independent randomisations, 2507 pregnant women were allocated to receive single-dose albendazole or placebo, and praziquantel or placebo; 2016 of their offspring were randomised to receive quarterly single-dose albendazole or placebo from age 15 months to 5 years. Primary outcomes were post-immunisation recall responses to BCG and tetanus antigens, and incidence of malaria, diarrhoea, and pneumonia; incidence of eczema was an important secondary outcome. Analysis was by intention-to-treat. Of 2345 live births, 1622 (69%) children remained in follow-up at age 5 years. 68% of mothers at enrolment, and 11% of five-year-olds, had helminth infections. Maternal hookworm and Schistosoma mansoni were effectively treated by albendazole and praziquantel, respectively; and childhood hookworm and Ascaris by quarterly albendazole. Incidence rates of malaria, diarrhoea, pneumonia, and eczema were 34, 65, 10 and 5 per 100 py, respectively. Albendazole during pregnancy caused an increased rate of eczema in the children (HR 1.58 (95% CI 1.15–2.17), p = 0.005). Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73–0.98), p = 0.03). There were no consistent effects of the interventions on any other outcome.Routine use of albendazole in pregnancy may not always be beneficial, even in tropical developing countries. By contrast, regular albendazole treatment in preschool children may have an additional benefit for malaria control where helminths and malaria are co-endemic. Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.Current Controlled Trials ISRCTN32849447

AB - Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to immunisation and modulate disease incidence in early childhood with both beneficial and detrimental effects.A randomised, double-blind, placebo-controlled trial was conducted in Entebbe, Uganda [ISRCTN32849447]. In three independent randomisations, 2507 pregnant women were allocated to receive single-dose albendazole or placebo, and praziquantel or placebo; 2016 of their offspring were randomised to receive quarterly single-dose albendazole or placebo from age 15 months to 5 years. Primary outcomes were post-immunisation recall responses to BCG and tetanus antigens, and incidence of malaria, diarrhoea, and pneumonia; incidence of eczema was an important secondary outcome. Analysis was by intention-to-treat. Of 2345 live births, 1622 (69%) children remained in follow-up at age 5 years. 68% of mothers at enrolment, and 11% of five-year-olds, had helminth infections. Maternal hookworm and Schistosoma mansoni were effectively treated by albendazole and praziquantel, respectively; and childhood hookworm and Ascaris by quarterly albendazole. Incidence rates of malaria, diarrhoea, pneumonia, and eczema were 34, 65, 10 and 5 per 100 py, respectively. Albendazole during pregnancy caused an increased rate of eczema in the children (HR 1.58 (95% CI 1.15–2.17), p = 0.005). Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73–0.98), p = 0.03). There were no consistent effects of the interventions on any other outcome.Routine use of albendazole in pregnancy may not always be beneficial, even in tropical developing countries. By contrast, regular albendazole treatment in preschool children may have an additional benefit for malaria control where helminths and malaria are co-endemic. Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.Current Controlled Trials ISRCTN32849447

U2 - 10.1371%2Fjournal.pone.0050325

DO - 10.1371%2Fjournal.pone.0050325

M3 - Journal article

VL - 7

SP - e50325 EP -

JO - PLoS ONE

JF - PLoS ONE

IS - 12

ER -