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Impact of processing conditions on inter-tablet coating thickness variations measured by terahertz in-line sensing

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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  • Hungyen Lin
  • Robert K. May
  • Michael J. Evans
  • Shuncong Zhong
  • Lynn F. Gladden
  • Yaochun Shen
  • J. Axel Zeitler
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<mark>Journal publication date</mark>2015
<mark>Journal</mark>Journal of Pharmaceutical Sciences
Issue number8
Volume104
Number of pages10
Pages (from-to)2513-2522
Publication StatusPublished
<mark>Original language</mark>English

Abstract

A novel in-line technique utilising pulsed terahertz radiation for direct measurement of the film coating thickness of individual tablets during the coating process was previously developed and demonstrated on a production-scale coater. Here, we use this technique to monitor the evolution of tablet film coating thickness and its inter-tablet variability during the coating process under a number of different process conditions that have been purposefully induced in the production-scale coating process. The changes that were introduced to the coating process include removing the baffles from the coater, adding uncoated tablets to the running process, halting the drum, blockage of spray guns and changes to the spray rate. The terahertz sensor was able to pick up the resulting changes in average coating thickness in the coating drum and we report the impact of these process changes on the resulting coating quality.