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Increased levels of plasma total tau in adult Down syndrome

Research output: Contribution to journalJournal article

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  • Takashi Kasai
  • Harutsugu Tatebe
  • Masaki Kondo
  • Ryotaro Ishii
  • Takuma Ohmichi
  • Wing Tung Esther Yeung
  • Masafumi Morimoto
  • Tomohiro Chiyonobu
  • Naoto Terada
  • David Allsop
  • Masanori Nakagawa
  • Toshiki Mizuno
  • Takahiko Tokuda
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Article numbere0188802
<mark>Journal publication date</mark>30/11/2017
<mark>Journal</mark>PLoS ONE
Issue number11
Volume12
Number of pages12
Publication statusPublished
Original languageEnglish

Abstract

Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured. We observed significantly increased plasma t-tau levels in the DS group compared to those in the control group. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS.