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Increased levels of plasma total tau in adult Down syndrome

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Increased levels of plasma total tau in adult Down syndrome. / Kasai, Takashi; Tatebe, Harutsugu; Kondo, Masaki; Ishii, Ryotaro; Ohmichi, Takuma; Yeung, Wing Tung Esther; Morimoto, Masafumi; Chiyonobu, Tomohiro; Terada, Naoto; Allsop, David; Nakagawa, Masanori; Mizuno, Toshiki; Tokuda, Takahiko.

In: PLoS ONE, Vol. 12, No. 11, e0188802, 30.11.2017.

Research output: Contribution to journalJournal article

Harvard

Kasai, T, Tatebe, H, Kondo, M, Ishii, R, Ohmichi, T, Yeung, WTE, Morimoto, M, Chiyonobu, T, Terada, N, Allsop, D, Nakagawa, M, Mizuno, T & Tokuda, T 2017, 'Increased levels of plasma total tau in adult Down syndrome', PLoS ONE, vol. 12, no. 11, e0188802. https://doi.org/10.1371/journal.pone.0188802

APA

Kasai, T., Tatebe, H., Kondo, M., Ishii, R., Ohmichi, T., Yeung, W. T. E., ... Tokuda, T. (2017). Increased levels of plasma total tau in adult Down syndrome. PLoS ONE, 12(11), [e0188802]. https://doi.org/10.1371/journal.pone.0188802

Vancouver

Kasai T, Tatebe H, Kondo M, Ishii R, Ohmichi T, Yeung WTE et al. Increased levels of plasma total tau in adult Down syndrome. PLoS ONE. 2017 Nov 30;12(11). e0188802. https://doi.org/10.1371/journal.pone.0188802

Author

Kasai, Takashi ; Tatebe, Harutsugu ; Kondo, Masaki ; Ishii, Ryotaro ; Ohmichi, Takuma ; Yeung, Wing Tung Esther ; Morimoto, Masafumi ; Chiyonobu, Tomohiro ; Terada, Naoto ; Allsop, David ; Nakagawa, Masanori ; Mizuno, Toshiki ; Tokuda, Takahiko. / Increased levels of plasma total tau in adult Down syndrome. In: PLoS ONE. 2017 ; Vol. 12, No. 11.

Bibtex

@article{2235142d591046049a2b134459123bea,
title = "Increased levels of plasma total tau in adult Down syndrome",
abstract = "Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured. We observed significantly increased plasma t-tau levels in the DS group compared to those in the control group. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS.",
author = "Takashi Kasai and Harutsugu Tatebe and Masaki Kondo and Ryotaro Ishii and Takuma Ohmichi and Yeung, {Wing Tung Esther} and Masafumi Morimoto and Tomohiro Chiyonobu and Naoto Terada and David Allsop and Masanori Nakagawa and Toshiki Mizuno and Takahiko Tokuda",
year = "2017",
month = "11",
day = "30",
doi = "10.1371/journal.pone.0188802",
language = "English",
volume = "12",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Increased levels of plasma total tau in adult Down syndrome

AU - Kasai, Takashi

AU - Tatebe, Harutsugu

AU - Kondo, Masaki

AU - Ishii, Ryotaro

AU - Ohmichi, Takuma

AU - Yeung, Wing Tung Esther

AU - Morimoto, Masafumi

AU - Chiyonobu, Tomohiro

AU - Terada, Naoto

AU - Allsop, David

AU - Nakagawa, Masanori

AU - Mizuno, Toshiki

AU - Tokuda, Takahiko

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured. We observed significantly increased plasma t-tau levels in the DS group compared to those in the control group. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS.

AB - Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured. We observed significantly increased plasma t-tau levels in the DS group compared to those in the control group. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS.

U2 - 10.1371/journal.pone.0188802

DO - 10.1371/journal.pone.0188802

M3 - Journal article

VL - 12

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 11

M1 - e0188802

ER -