Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Increased levels of plasma total tau in adult Down syndrome
AU - Kasai, Takashi
AU - Tatebe, Harutsugu
AU - Kondo, Masaki
AU - Ishii, Ryotaro
AU - Ohmichi, Takuma
AU - Yeung, Wing Tung Esther
AU - Morimoto, Masafumi
AU - Chiyonobu, Tomohiro
AU - Terada, Naoto
AU - Allsop, David
AU - Nakagawa, Masanori
AU - Mizuno, Toshiki
AU - Tokuda, Takahiko
PY - 2017/11/30
Y1 - 2017/11/30
N2 - Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured. We observed significantly increased plasma t-tau levels in the DS group compared to those in the control group. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS.
AB - Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer’s disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the established biomarkers for the diagnosis of AD, suggesting the potential value of t-tau as a biomarker for dementia in DS. In this study, plasma levels of t-tau in 21 patients with DS and 22 control participants were measured. We observed significantly increased plasma t-tau levels in the DS group compared to those in the control group. Moreover, age dependent correlation of plasma t-tau was only found in the DS group, and not in the control group. These findings suggest that elevated plasma t-tau levels reflect AD pathology and therefore have potential as an objective biomarker to detect dementia in adult DS.
U2 - 10.1371/journal.pone.0188802
DO - 10.1371/journal.pone.0188802
M3 - Journal article
VL - 12
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - e0188802
ER -