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Influenza C in Lancaster, UK, in the winter of 2014-2015

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Influenza C in Lancaster, UK, in the winter of 2014-2015. / Atkinson, Kate V.; Bishop, Lisa A.; Rhodes, Glenn et al.
In: Scientific Reports, Vol. 7, 46578, 13.04.2017.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Atkinson, KV, Bishop, LA, Rhodes, G, Salez, N, McEwan, NR, Hegarty, MJ, Robey, J, Harding, N, Wetherell, S, Lauder, RM, Pickup, RW, Wilkinson, M & Gatherer, D 2017, 'Influenza C in Lancaster, UK, in the winter of 2014-2015', Scientific Reports, vol. 7, 46578. https://doi.org/10.1038/srep46578

APA

Atkinson, K. V., Bishop, L. A., Rhodes, G., Salez, N., McEwan, N. R., Hegarty, M. J., Robey, J., Harding, N., Wetherell, S., Lauder, R. M., Pickup, R. W., Wilkinson, M., & Gatherer, D. (2017). Influenza C in Lancaster, UK, in the winter of 2014-2015. Scientific Reports, 7, Article 46578. https://doi.org/10.1038/srep46578

Vancouver

Atkinson KV, Bishop LA, Rhodes G, Salez N, McEwan NR, Hegarty MJ et al. Influenza C in Lancaster, UK, in the winter of 2014-2015. Scientific Reports. 2017 Apr 13;7:46578. doi: 10.1038/srep46578

Author

Atkinson, Kate V. ; Bishop, Lisa A. ; Rhodes, Glenn et al. / Influenza C in Lancaster, UK, in the winter of 2014-2015. In: Scientific Reports. 2017 ; Vol. 7.

Bibtex

@article{1c75c6ba2eca48719d6dea46a1b7091c,
title = "Influenza C in Lancaster, UK, in the winter of 2014-2015",
abstract = "Influenza C is not included in the annual seasonal influenza vaccine, and has historically been regarded as a minor respiratory pathogen. However, recent work has highlighted its potential role as a cause of pneumonia in infants. We performed nasopharyngeal or nasal swabbing and/or serum sampling (n = 148) in Lancaster, UK, over the winter of 2014-2015. Using enzyme-linked immunosorbent assay (ELISA), we obtain seropositivity of 77%. By contrast, only 2 individuals, both asymptomatic adults, were influenza C-positive by polymerase chain reaction (PCR). Deep sequencing of nasopharyngeal samples produced partial sequences for 4 genome segments in one of these patients. Bayesian phylogenetic analysis demonstrated that the influenza C genome from this individual is evolutionarily distant to those sampled in recent years and represents a novel genome constellation, indicating that it may be a product of a decades-old reassortment event. Although we find no evidence that influenza C was a significant respiratory pathogen during the winter of 2014-2015 in Lancaster, we confirm previous observations of seropositivity in the majority of the population. (170 words).",
author = "Atkinson, {Kate V.} and Bishop, {Lisa A.} and Glenn Rhodes and Nicolas Salez and McEwan, {Neil R.} and Hegarty, {Matthew J.} and Julie Robey and Nicola Harding and Simon Wetherell and Lauder, {Robert M.} and Pickup, {Roger W.} and Mark Wilkinson and Derek Gatherer",
year = "2017",
month = apr,
day = "13",
doi = "10.1038/srep46578",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Influenza C in Lancaster, UK, in the winter of 2014-2015

AU - Atkinson, Kate V.

AU - Bishop, Lisa A.

AU - Rhodes, Glenn

AU - Salez, Nicolas

AU - McEwan, Neil R.

AU - Hegarty, Matthew J.

AU - Robey, Julie

AU - Harding, Nicola

AU - Wetherell, Simon

AU - Lauder, Robert M.

AU - Pickup, Roger W.

AU - Wilkinson, Mark

AU - Gatherer, Derek

PY - 2017/4/13

Y1 - 2017/4/13

N2 - Influenza C is not included in the annual seasonal influenza vaccine, and has historically been regarded as a minor respiratory pathogen. However, recent work has highlighted its potential role as a cause of pneumonia in infants. We performed nasopharyngeal or nasal swabbing and/or serum sampling (n = 148) in Lancaster, UK, over the winter of 2014-2015. Using enzyme-linked immunosorbent assay (ELISA), we obtain seropositivity of 77%. By contrast, only 2 individuals, both asymptomatic adults, were influenza C-positive by polymerase chain reaction (PCR). Deep sequencing of nasopharyngeal samples produced partial sequences for 4 genome segments in one of these patients. Bayesian phylogenetic analysis demonstrated that the influenza C genome from this individual is evolutionarily distant to those sampled in recent years and represents a novel genome constellation, indicating that it may be a product of a decades-old reassortment event. Although we find no evidence that influenza C was a significant respiratory pathogen during the winter of 2014-2015 in Lancaster, we confirm previous observations of seropositivity in the majority of the population. (170 words).

AB - Influenza C is not included in the annual seasonal influenza vaccine, and has historically been regarded as a minor respiratory pathogen. However, recent work has highlighted its potential role as a cause of pneumonia in infants. We performed nasopharyngeal or nasal swabbing and/or serum sampling (n = 148) in Lancaster, UK, over the winter of 2014-2015. Using enzyme-linked immunosorbent assay (ELISA), we obtain seropositivity of 77%. By contrast, only 2 individuals, both asymptomatic adults, were influenza C-positive by polymerase chain reaction (PCR). Deep sequencing of nasopharyngeal samples produced partial sequences for 4 genome segments in one of these patients. Bayesian phylogenetic analysis demonstrated that the influenza C genome from this individual is evolutionarily distant to those sampled in recent years and represents a novel genome constellation, indicating that it may be a product of a decades-old reassortment event. Although we find no evidence that influenza C was a significant respiratory pathogen during the winter of 2014-2015 in Lancaster, we confirm previous observations of seropositivity in the majority of the population. (170 words).

U2 - 10.1038/srep46578

DO - 10.1038/srep46578

M3 - Journal article

C2 - 28406194

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 46578

ER -