TY - JOUR

T1 - Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia

AU - EFSA Scientific Committee

AU - Ockleford, Colin

AU - Adriaanse, Paulien

AU - Berny, Philippe

AU - Brock, Theodorus

AU - Duquesne, Sabine

AU - Grilli, Sandro

AU - Hernandez-Jerez, Antonio F

AU - Bennekou, Susanne Hougaard

AU - Klein, Michael

AU - Kuhl, Thomas

AU - Laskowski, Ryszard

AU - Machera, Kyriaki

AU - Pelkonen, Olavi

AU - Pieper, Silvia

AU - Smith, Rob

AU - Stemmer, Michael

AU - Sundh, Ingvar

AU - Teodorovic, Ivana

AU - Tiktak, Aaldrik

AU - Topping, Chris J

AU - Wolterink, Gerrit

AU - Angeli, Karine

AU - Fritsche, Ellen

AU - Leist, Marcel

AU - Mantovani, Alberto

AU - Menendez, Pablo

AU - Price, Anna

AU - Viviani, Barbara

AU - Chiusolo, Arianna

AU - Ruffo, Federica

AU - Terron, Andrea

N1 - doi: 10.2903/j.efsa.2017.4691

PY - 2017/3

Y1 - 2017/3

N2 - Abstract In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA).

AB - Abstract In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA).

KW - AOP

KW - Parkinson's disease

KW - childhood leukaemia

KW - infant leukaemia

KW - pesticides

KW - epidemiology

U2 - 10.2903/j.efsa.2017.4691

DO - 10.2903/j.efsa.2017.4691

M3 - Journal article

VL - 15

JO - EFSA Journal

JF - EFSA Journal

SN - 1831-4732

IS - 3

M1 - 04691

ER -