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Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD

Research output: Contribution to journalJournal article

Published

  • VL Hill
  • N Passerini
  • DQM Craig
  • M Vickers
  • J Anwar
  • LC Feely
Journal publication date1998
JournalJournal of thermal analysis and calorimetry
Journal number2
Volume54
Number of pages13
Pages673-685
Original languageEnglish

Abstract

Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.