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Ion transport through chemically induced pores in protein-free phospholipid membranes

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Ion transport through chemically induced pores in protein-free phospholipid membranes. / Gurtovenko, Andrey A.; Anwar, Jamshed.

In: Journal of Physical Chemistry B, Vol. 111, No. 47, 29.11.2007, p. 13379-13382.

Research output: Contribution to journalJournal article

Harvard

Gurtovenko, AA & Anwar, J 2007, 'Ion transport through chemically induced pores in protein-free phospholipid membranes', Journal of Physical Chemistry B, vol. 111, no. 47, pp. 13379-13382. https://doi.org/10.1021/jp075631v

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Gurtovenko, Andrey A. ; Anwar, Jamshed. / Ion transport through chemically induced pores in protein-free phospholipid membranes. In: Journal of Physical Chemistry B. 2007 ; Vol. 111, No. 47. pp. 13379-13382.

Bibtex

@article{bce78f59d8a34804ae698d50766e6ce3,
title = "Ion transport through chemically induced pores in protein-free phospholipid membranes",
abstract = "We address the possibility of being able to induce the trafficking of salt ions and other solutes across cell membranes without the use of specific protein-based transporters or pumps. On the basis of realistic atomic-scale molecular dynamics simulations, we demonstrate that transmembrane ionic leakage can be initiated by chemical means, in this instance through addition of dimethyl sulfoxide (DMSO), a solvent widely used in cell biology. Our results provide compelling evidence that the small amphiphilic solute DMSO is able to induce transient defects (water pores) in membranes and to promote a subsequent diffusive pore-mediated transport of salt ions. The findings are consistent with available experimental data and offer a molecularlevel explanation for the experimentally observed activities of DMSO solvent as an efficient penetration enhancer and a cryoprotectant, as well as an analgesic. Our findings suggest that transient pore formation by chemical means could emerge as an important general principle for therapeutics.",
keywords = "LIPID-MEMBRANES, PARTICLE MESH EWALD, COMPUTER-SIMULATIONS, BILAYERS, MOLECULAR-DYNAMICS SIMULATIONS, FREE-ENERGY, DIMETHYL-SULFOXIDE, CHARGE IMBALANCE, DIMETHYLSULFOXIDE, TEMPERATURE",
author = "Gurtovenko, {Andrey A.} and Jamshed Anwar",
year = "2007",
month = nov
day = "29",
doi = "10.1021/jp075631v",
language = "English",
volume = "111",
pages = "13379--13382",
journal = "Journal of Physical Chemistry B",
issn = "1520-6106",
publisher = "AMER CHEMICAL SOC",
number = "47",

}

RIS

TY - JOUR

T1 - Ion transport through chemically induced pores in protein-free phospholipid membranes

AU - Gurtovenko, Andrey A.

AU - Anwar, Jamshed

PY - 2007/11/29

Y1 - 2007/11/29

N2 - We address the possibility of being able to induce the trafficking of salt ions and other solutes across cell membranes without the use of specific protein-based transporters or pumps. On the basis of realistic atomic-scale molecular dynamics simulations, we demonstrate that transmembrane ionic leakage can be initiated by chemical means, in this instance through addition of dimethyl sulfoxide (DMSO), a solvent widely used in cell biology. Our results provide compelling evidence that the small amphiphilic solute DMSO is able to induce transient defects (water pores) in membranes and to promote a subsequent diffusive pore-mediated transport of salt ions. The findings are consistent with available experimental data and offer a molecularlevel explanation for the experimentally observed activities of DMSO solvent as an efficient penetration enhancer and a cryoprotectant, as well as an analgesic. Our findings suggest that transient pore formation by chemical means could emerge as an important general principle for therapeutics.

AB - We address the possibility of being able to induce the trafficking of salt ions and other solutes across cell membranes without the use of specific protein-based transporters or pumps. On the basis of realistic atomic-scale molecular dynamics simulations, we demonstrate that transmembrane ionic leakage can be initiated by chemical means, in this instance through addition of dimethyl sulfoxide (DMSO), a solvent widely used in cell biology. Our results provide compelling evidence that the small amphiphilic solute DMSO is able to induce transient defects (water pores) in membranes and to promote a subsequent diffusive pore-mediated transport of salt ions. The findings are consistent with available experimental data and offer a molecularlevel explanation for the experimentally observed activities of DMSO solvent as an efficient penetration enhancer and a cryoprotectant, as well as an analgesic. Our findings suggest that transient pore formation by chemical means could emerge as an important general principle for therapeutics.

KW - LIPID-MEMBRANES

KW - PARTICLE MESH EWALD

KW - COMPUTER-SIMULATIONS

KW - BILAYERS

KW - MOLECULAR-DYNAMICS SIMULATIONS

KW - FREE-ENERGY

KW - DIMETHYL-SULFOXIDE

KW - CHARGE IMBALANCE

KW - DIMETHYLSULFOXIDE

KW - TEMPERATURE

U2 - 10.1021/jp075631v

DO - 10.1021/jp075631v

M3 - Journal article

VL - 111

SP - 13379

EP - 13382

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

SN - 1520-6106

IS - 47

ER -