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Leishmania sand fly interaction: progress and challenges

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Leishmania sand fly interaction : progress and challenges. / Bates, Paul A.

In: Current Opinion in Microbiology, Vol. 11, No. 4, 08.2008, p. 340-344.

Research output: Contribution to journalJournal article

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Bates, PA 2008, 'Leishmania sand fly interaction: progress and challenges', Current Opinion in Microbiology, vol. 11, no. 4, pp. 340-344. https://doi.org/10.1016/j.mib.2008.06.003

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Bates, Paul A. / Leishmania sand fly interaction : progress and challenges. In: Current Opinion in Microbiology. 2008 ; Vol. 11, No. 4. pp. 340-344.

Bibtex

@article{a5ecce1b819a41d5aaf03995bdc0daaf,
title = "Leishmania sand fly interaction: progress and challenges",
abstract = "Complex interactions occurs between Leishmania parasites and their sand fly vectors. Promastigotes of Leishmania live exclusively within the gut, possess flagella and are motile, and kinesins, kinases and G proteins have been described that play a role in regulating flagellar assembly. Movement within the gut is not random: promastigotes can detect gradients of solutes via chemotaxis and osmotaxis. Further they use their flagella to attach to the fly midgut using surface glyconconjugates, a key step in establishment of the infection. Differentiation of mammal-infective stages is characterised by significant biochemical and cellular remodelling. Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages.",
keywords = "Animals, Cell Adhesion, Disease Vectors, Gastrointestinal Tract, Leishmania, Locomotion, Psychodidae",
author = "Bates, {Paul A}",
year = "2008",
month = aug,
doi = "10.1016/j.mib.2008.06.003",
language = "English",
volume = "11",
pages = "340--344",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",
number = "4",

}

RIS

TY - JOUR

T1 - Leishmania sand fly interaction

T2 - progress and challenges

AU - Bates, Paul A

PY - 2008/8

Y1 - 2008/8

N2 - Complex interactions occurs between Leishmania parasites and their sand fly vectors. Promastigotes of Leishmania live exclusively within the gut, possess flagella and are motile, and kinesins, kinases and G proteins have been described that play a role in regulating flagellar assembly. Movement within the gut is not random: promastigotes can detect gradients of solutes via chemotaxis and osmotaxis. Further they use their flagella to attach to the fly midgut using surface glyconconjugates, a key step in establishment of the infection. Differentiation of mammal-infective stages is characterised by significant biochemical and cellular remodelling. Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages.

AB - Complex interactions occurs between Leishmania parasites and their sand fly vectors. Promastigotes of Leishmania live exclusively within the gut, possess flagella and are motile, and kinesins, kinases and G proteins have been described that play a role in regulating flagellar assembly. Movement within the gut is not random: promastigotes can detect gradients of solutes via chemotaxis and osmotaxis. Further they use their flagella to attach to the fly midgut using surface glyconconjugates, a key step in establishment of the infection. Differentiation of mammal-infective stages is characterised by significant biochemical and cellular remodelling. Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages.

KW - Animals

KW - Cell Adhesion

KW - Disease Vectors

KW - Gastrointestinal Tract

KW - Leishmania

KW - Locomotion

KW - Psychodidae

U2 - 10.1016/j.mib.2008.06.003

DO - 10.1016/j.mib.2008.06.003

M3 - Journal article

C2 - 18625337

VL - 11

SP - 340

EP - 344

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 4

ER -