Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Leishmania sand fly interaction
T2 - progress and challenges
AU - Bates, Paul A
PY - 2008/8
Y1 - 2008/8
N2 - Complex interactions occurs between Leishmania parasites and their sand fly vectors. Promastigotes of Leishmania live exclusively within the gut, possess flagella and are motile, and kinesins, kinases and G proteins have been described that play a role in regulating flagellar assembly. Movement within the gut is not random: promastigotes can detect gradients of solutes via chemotaxis and osmotaxis. Further they use their flagella to attach to the fly midgut using surface glyconconjugates, a key step in establishment of the infection. Differentiation of mammal-infective stages is characterised by significant biochemical and cellular remodelling. Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages.
AB - Complex interactions occurs between Leishmania parasites and their sand fly vectors. Promastigotes of Leishmania live exclusively within the gut, possess flagella and are motile, and kinesins, kinases and G proteins have been described that play a role in regulating flagellar assembly. Movement within the gut is not random: promastigotes can detect gradients of solutes via chemotaxis and osmotaxis. Further they use their flagella to attach to the fly midgut using surface glyconconjugates, a key step in establishment of the infection. Differentiation of mammal-infective stages is characterised by significant biochemical and cellular remodelling. Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages.
KW - Animals
KW - Cell Adhesion
KW - Disease Vectors
KW - Gastrointestinal Tract
KW - Leishmania
KW - Locomotion
KW - Psychodidae
U2 - 10.1016/j.mib.2008.06.003
DO - 10.1016/j.mib.2008.06.003
M3 - Journal article
C2 - 18625337
VL - 11
SP - 340
EP - 344
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 4
ER -