The experiences of LGBT asylum seekers in the UK are the focus of this chapter. The relative invisibility of LGBT asylum seekers in social work literature and research is acknowledged. Data from interviews undertaken as part of a small scale research study is used to highlight issues of psychological stress, safety, social isolation and resilience and survival. This material is discussed in relation to models of minority stress, discrimination, social determinants of health, and human rights. A holistic approach to practice in response to an opening vignette, is presented with reference to the importance of advocacy and cross-sector partnership working.