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Lineage structures in the genome sequences of three Epstein-Barr virus strains

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Lineage structures in the genome sequences of three Epstein-Barr virus strains. / McGeoch, Duncan J.; Gatherer, Derek.
In: Virology, Vol. 359, No. 1, 01.03.2007, p. 1-5.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

McGeoch, DJ & Gatherer, D 2007, 'Lineage structures in the genome sequences of three Epstein-Barr virus strains', Virology, vol. 359, no. 1, pp. 1-5. https://doi.org/10.1016/j.virol.2006.10.009

APA

McGeoch, D. J., & Gatherer, D. (2007). Lineage structures in the genome sequences of three Epstein-Barr virus strains. Virology, 359(1), 1-5. https://doi.org/10.1016/j.virol.2006.10.009

Vancouver

McGeoch DJ, Gatherer D. Lineage structures in the genome sequences of three Epstein-Barr virus strains. Virology. 2007 Mar 1;359(1):1-5. doi: 10.1016/j.virol.2006.10.009

Author

McGeoch, Duncan J. ; Gatherer, Derek. / Lineage structures in the genome sequences of three Epstein-Barr virus strains. In: Virology. 2007 ; Vol. 359, No. 1. pp. 1-5.

Bibtex

@article{2c91d146b8e047ecad7463c2de89ead8,
title = "Lineage structures in the genome sequences of three Epstein-Barr virus strains",
abstract = "Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were identified with strains at each in two major groupings. All three possible patterns of strain associations were represented across the seven loci. Tree-building studies supported the existence of two distinct lineages in each case, and occurrence of recombination between lineages therefore has to be invoked to account for the observed genotypes of virus strains.",
keywords = "Base Sequence, DNA, Viral, Evolution, Molecular, Genetic Variation, Genome, Viral, Genotype, Herpesvirus 4, Human, Recombination, Genetic, Sequence Alignment, Sequence Homology, Nucleic Acid",
author = "McGeoch, {Duncan J.} and Derek Gatherer",
year = "2007",
month = mar,
day = "1",
doi = "10.1016/j.virol.2006.10.009",
language = "English",
volume = "359",
pages = "1--5",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Lineage structures in the genome sequences of three Epstein-Barr virus strains

AU - McGeoch, Duncan J.

AU - Gatherer, Derek

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were identified with strains at each in two major groupings. All three possible patterns of strain associations were represented across the seven loci. Tree-building studies supported the existence of two distinct lineages in each case, and occurrence of recombination between lineages therefore has to be invoked to account for the observed genotypes of virus strains.

AB - Whole genome sequences for three Epstein-Barr virus strains (B95-8, GD1 and AG876) were aligned and compared. In addition to known variable loci (including type-specific alleles for the EBNA2, EBNA3A, EBNA3B and EBNA3C genes, plus the EBNA1 and LMP1 genes), seven large-scale regions of lower-level diversity were identified with strains at each in two major groupings. All three possible patterns of strain associations were represented across the seven loci. Tree-building studies supported the existence of two distinct lineages in each case, and occurrence of recombination between lineages therefore has to be invoked to account for the observed genotypes of virus strains.

KW - Base Sequence

KW - DNA, Viral

KW - Evolution, Molecular

KW - Genetic Variation

KW - Genome, Viral

KW - Genotype

KW - Herpesvirus 4, Human

KW - Recombination, Genetic

KW - Sequence Alignment

KW - Sequence Homology, Nucleic Acid

U2 - 10.1016/j.virol.2006.10.009

DO - 10.1016/j.virol.2006.10.009

M3 - Journal article

C2 - 17097710

VL - 359

SP - 1

EP - 5

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -