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Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.

Research output: Contribution to journalJournal article

Published

  • N. J. Barber
  • X. Zhang
  • G. Zhu
  • R. Pramanik
  • J. A. Barber
  • Francis L. Martin
  • J. D. H. Morris
  • G. H. Muir
Journal publication date12/2006
JournalProstate Cancer and Prostatic Diseases
Journal number4
Volume9
Number of pages7
Pages407-413
Original languageEnglish

Abstract

Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.